Metabolic Syndrome Increases CRC Risk in Healthy-Weight Women

Women with metabolically unhealthy phenotypes had higher risks of colorectal cancer than those who were metabolically healthy, even in women who had healthy weights.
Women with metabolically unhealthy phenotypes had higher risks of colorectal cancer than those who were metabolically healthy, even in women who had healthy weights.

HealthDay News - Even normal-weight women may be at greater risk for colorectal cancer if they have certain traits, such as elevated triglycerides, low high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting glucose, according to a study published online Feb. 1 in Cancer Epidemiology, Biomarkers & Prevention.

The study involved normal-weight postmenopausal women, aged 50 to 79. The research team's analysis involved 5,068 women enrolled in the Women's Health Initiative, a 15-year study led by the U.S. National Institutes of Health.

One-third of the women in the study were deemed metabolically unhealthy, meaning they had two or more risk factors of metabolic syndrome (excluding waist measurement). 

The researchers found that normal-weight women who were metabolically unhealthy had an increased risk of colorectal cancer (hazard ratio, 1.49; 95 percent confidence interval, 1.02 to 2.18), compared with metabolically-healthy women.

"A metabolically unhealthy phenotype was associated with higher risk of colorectal cancer among normal-weight women," the authors write. "Normal-weight women should still be evaluated for metabolic health and appropriate steps taken to reduce their risk of colorectal cancer."

Reference

Liang X, Margolis KL, Hendryx M, et al. Metabolic Phenotype and Risk of Colorectal Cancer in Normal-Weight Postmenopausal Women [published online February 1, 2017].  Canc Epid Biomarkers. doi: 0.1158/1055-9965.EPI-16-0761 

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