Metabolic Syndrome Associated With Mild Cognitive Impairment

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The presence of metabolic syndrome may be linked to an increase in risk for mild cognitive impairment.
The presence of metabolic syndrome may be linked to an increase in risk for mild cognitive impairment.

(HealthDay News) — The incidence of mild cognitive impairment and mild cognitive impairment progression to dementia is increased in association with metabolic syndrome, according to a study published in JAMA Neurology.

Tze Pin Ng, MD, from the National University of Singapore, and colleagues examined the correlation for metabolic syndrome and its component cardiovascular (CV) risk factors with the incidence of mild cognitive impairment and its progression to dementia in a prospective longitudinal study. 

Participants were a population-based sample of 1519 cognitively normal adults aged 55 years and older (mean age, 64.9 years; 64.8% women).

The researchers found that the risk for incident mild cognitive impairment was increased in association with baseline characteristics of metabolic syndrome (hazard ratio [HR]=1.46), central obesity (HR=1.41), diabetes (HR=2.84), dyslipidemia (HR=1.48), and 3 or more component CV risk factors (HR=1.58).

The risk risk mild cognitive impairment progression to dementia was increased in association with baseline characteristics of metabolic syndrome (HR=4.25), diabetes (HR=2.47), and 3 or more component CV risk factors (HR=4.92).

"The metabolic syndrome was associated with an increased incidence of mild cognitive impairment and progression to dementia," the researchers wrote. "Identifying individuals with diabetes mellitus or the metabolic syndrome with or without mild cognitive impairment is a promising approach in early interventions to prevent or slow progression to dementia."

Reference

  1. Ng TP, Feng L, Nyunt MSZ, et al. Metabolic Syndrome and the Risk of Mild Cognitive Impairment and Progression to Dementia: Follow-up of the Singapore Longitudinal Ageing Study Cohort. JAMA Neurol. 2016. doi:10.1001/jamaneurol.2015.4899.
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