In CKD, Masked Hypertension Is Common, Tied to CV Target Organ Damage

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In chronic kidney disease, masked hypertension is common and linked to low eGFR and proteinuria.
In chronic kidney disease, masked hypertension is common and linked to low eGFR and proteinuria.

(HealthDay News) — For patients with chronic kidney disease (CKD), masked hypertension is common and is associated with reduced kidney function and cardiovascular (CV) target organ damage, according to a study published in the Clinical Journal of the American Society of Nephrology.

Paul E. Drawz, MD, MHS, from the University of Minnesota in Minneapolis, and colleagues examined the correlation between masked hypertension and kidney function and markers of CV target organ damage in a cross-sectional study. They measured 24-hour ambulatory blood pressure in 1492 men and women with CKD. Based on clinic and 24-hour ambulatory blood pressure, participants were categorized as having controlled blood pressure, white-coat, masked, and sustained hypertension.

The researchers found that 49.3%, 4.1%, 27.8%, and 18.8% of patients had controlled blood pressure, white-coat, masked, and sustained hypertension, respectively. Masked hypertension was independently associated with low estimated glomerular filtration rate (eGFR), higher proteinuria, and higher left ventricular mass and pulse wave velocity compared with controlled blood pressure. Lower eGFR was seen for participants with masked hypertension only in the presence of elevated nighttime blood pressure.

"Masked hypertension is common in patients with CKD and associated with low eGFR, proteinuria, and cardiovascular target organ damage," the researchers wrote.

Reference

  1. Drawz PE, Alper AB, Anderson AH, et al. Masked Hypertension and Elevated Nighttime Blood Pressure in CKD: Prevalence and Association with Target Organ Damage. Clin J Am Soc Nephrol. 2016. doi:10.2215/​CJN.08530815.
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