Exercise Decreases CV Risk After Hodgkin Lymphoma

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Exercise Decreases CV Risk After Hodgkin Lymphoma
Exercise Decreases CV Risk After Hodgkin Lymphoma

(HealthDay News) — Exercise may lower the risk for treatment-related cardiovascular events in adult survivors of childhood Hodgkin lymphoma, according to research published in the Journal of Clinical Oncology.

Lee W. Jones, PhD, of the Memorial Sloan Kettering Cancer Center in New York City, and colleagues used questionnaires to evaluate exercise behavior and occurrence of cardiovascular (CV) events in 1,187 adult survivors (median age, 31.2 years) of childhood Hodgkin lymphoma.

Over a median follow-up of 11.9 years (range, 1.7 years to 14.3 years), that the cumulative incidence of any CV event at 10 years was higher among cancer survivors reporting zero metabolic equivalent (MET) hours/week−1 of vigorous-intensity exercise (12.2%) than those reporting ≥9 MET hours/week−1 (5.2%), the researchers found.

Compared with cancer survivors reporting zero MET hours/week−1, the adjusted rate ratio for any CV event was 0.87 (95%, 0.56-1.34) for those reporting three to six MET hours/week−1, 0.45 (95% CI, 0.26-0.8) for those reporting 9 to 12 MET hours/week−1, and 0.47 (95% CI, 0.23-0.95) for those reporting 15 to 21 MET hours/week−1.

Compared with cancer survivors who did not meet the guidelines for ≥9 MET hours/week−1 of vigorous-intensity exercise, those who met the guidelines had a 51% reduction in the risk for any CV event.

"Vigorous exercise was associated with a lower risk of cardiovascular events in a dose-dependent manner independent of cardiovascular risk profile and treatment in survivors of Hodgkin lymphoma," the researchers wrote.

Two authors disclosed financial ties to pharmaceutical and/or biomedical companies.

Reference

  1. Jones LW et al. J Clin Oncol. 2014;doi:10.1200/JCO.2014.56.7511.
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