Race Impacts Sex Differences in CHD Event Risk

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Sex differences in coronary heart disease event risk varies by race.
Sex differences in coronary heart disease event risk varies by race.

(HealthDay News) — White patients have larger sex differences in the risk for incident coronary heart disease (CHD) events than black patients, according to a study published in the Journal of the American Heart Association.

Catherine Kim, MD, MPH, from the University of Michigan in Ann Arbor, and colleagues examined whether menopause type and race impact sex differences in CHD events. Data were included for 23,086 participants enrolled in the Reasons for Geographic and Racial Differences in Stroke cohort between 2003 and 2007, without CHD at baseline.

After adjustment for multiple confounding variables, the researchers found that the risk for nonfatal events was reduced for white women in natural menopause (HR=0.45; 95% CI, 0.31-0.66) and surgical menopause (HR=0.65; 95% CI, 0.42-0.99), compared with white men.

The risk for nonfatal events was marginally reduced for black women in natural menopause (HR=0.69; 95% CI, 0.47-1.03) but not in surgical menopause (HR=0.81; 95% CI, 0.51-1.29), compared with black men.

Compared with men, women had a lower risk for acute CHD death, irrespective of menopause type or race.

"In both blacks and whites, women had a lower risk of total CHD events than men, regardless of menopause category," the researchers. "Patterns varied by race, with no significant sex differences observed in nonfatal CHD risk among blacks."

Reference

  1. Kim C et al. J Am Heart Assoc. 2015;doi:10.1161/JAHA.115.001881.
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