CAD, MI Risk May Be Higher With Non-O Blood Group
Coronary artery disease and myocardial infarction risk may be higher with non-O blood group.
(HealthDay News) — Having non-O blood group may be an independent risk factor for coronary artery disease (CAD) and myocardial infarction (MI), according to a meta-analysis published in The American Journal of Cardiology.
Hisato Takagi, MD, PhD, and Takuya Umemoto, MD, PhD, on behalf of the All-Literature Investigation of Cardiovascular Evidence Group, conducted a literature review (January 2001 to March 2015) to identify case-control, cross-sectional or cohort studies reporting adjusted odds ratios (ORs) and hazard ratios (HRs) for CAD in subjects with non-O vs. O blood group.
The researchers included 12 relative risk estimates in 10 eligible studies. Based on pooled analysis, the non-O blood group was associated with a statistically significant 14% increase in CAD incidence compared with O blood group (OR/HR=1.14; 95% CI, 1.04-1.25).
No evidence of significant publication bias was seen.
When eight studies reporting data regarding (acute) MI were pooled, similar statistically significant results unfavorable to the non-O blood group were seen (OR/HR=1.16; 95% CI, 1.02-1.31).
"In conclusion, we found that based on a meta-analysis of 10 studies enrolling a total of 174,945 participants, non-O blood group appears to be an independent risk factor for CAD and MI," the researchers wrote.