Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified.
Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.
Bilateral hip or knee osteoarthritis was significantly associated with a 16% to 25% increased risk for incident diabetes.
Rates of incident clinical vertebral fracture, incident nonvertebral fracture, hip fracture, and clinical fractures decreased 6 months after initiation of teriparatide.
Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.
Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.
Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.
A corrected HbA1C factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.
Investigators compared biomarkers in patients who eventually developed radiographic osteolytic lesions to those who did not.
Researchers observed no change in bone mineral density in patients with early and active rheumatoid arthritis who were treated with prednisone or prednisolone vs placebo.
Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.
Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.
Screening with bone measurement is recommended for women. Younger women are at more risk.
High levels of serotonin are predictive of an increased risk for hip fracture, nonvertebral osteoporotic fracture, and incident fractures in older men.
Investigators sought to determine whether female reproductive and hormonal factors affect the incidence of total knee arthroplasty for osteoarthritis.
Men with accelerated bone loss have lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices compared with men without accelerated bone loss.
Negative effects of 2-hour glucose was pronounced at the cortical-bone-dominant sites in women.
Vitamin D levels in preterm infants are significantly correlated with optimal calcium homeostasis and bone mineralization of the femur.
For patients with osteopenia or osteoporosis, taking a bisphosphonate drug holiday is associated with increased risk of fracture for patients with lower femoral neck bone mineral density or T scores.
Investigators sought to determine whether both restrictive and purging types of anorexia nervosa effect bone metabolism.
The 1-year cardiovascular mortality hazard ratio (HR) for alendronate users was 0.33 (95% CI, 0.17 to 0.65) and 0.55 for incident myocardial infarction (95% CI, 0.34 to 0.89).
Anxiety levels are associated with bone mineral density and fracture risk in the lumbar spine and femoral neck among postmenopausal women.
Studies on the antifracture effectiveness of antiosteoporosis medications (or nonpharmacologic treatments) should account for death as a competing risk.
Researchers investigated whether patients with SLE receive lipid testing and statin prescriptions comparably with patients with diabetes.
Findings do not support a role for subclinical thyroid dysfunction as a biomarker for bone-related outcomes in older men.
Researchers showed that improved glycemic control is associated with higher bone resorption, possibly reflecting normalization rather than an abnormal increase in bone resorption.
Researchers sought to determine the predictive value of tibiofemoral MRI, patellofemoral MRI, and KLG1 for the incidence of clinical or radiographic knee OA.
A high stress fracture rate in oligo-amenorrheic athletes, who have whole body, less head and hip, areal bone mineral density (BMD) measures comparable to those of control patients, indicates that BMD in these women may need to be even higher to avoid fractures.
Researchers found that estimation of hip fracture risk without accounting for death as a competing event results in an overestimation of fracture risk.
The USPSTF has released recommendations for vitamin D and calcium supplementation for the primary prevention of fractures in community-dwelling adults.
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