Bone Metabolism

Denosumab May Increase BMD in Women With Primary Hyperparathyroidism

Denosumab May Increase BMD in Women With Primary Hyperparathyroidism

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Study assessed the effect of denosumab on bone mineral density and incident fractures in older adults with primary hyperparathyroidism who could not undergo or refused surgery.

BMD and Parathyroid Hormone Levels in Pseudohypoparathyroidism 1B

BMD and Parathyroid Hormone Levels in Pseudohypoparathyroidism 1B

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Study showed that parathyroid hormone was a significant predictor of lumbar spine bone mineral density Z-score for pseudohypoparathyroidism 1B patients.

Lower Bone Mineral Density May Increase Intracranial Aneurysm Risk

Lower Bone Mineral Density May Increase Intracranial Aneurysm Risk

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A lower bone mineral density in the lumbar spine, femoral neck, and hip is associated with an increased risk for intracranial aneurysm.

Effect of Biologic DMARDs on Spinal Fracture Risk in Ankylosing Spondylitis

Effect of Biologic DMARDs on Spinal Fracture Risk in Ankylosing Spondylitis

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The use of biologic disease-modifying antirheumatic drugs has no medium-term effect on the risk for spinal fractures among patients with ankylosing spondylitis.

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

Romosozumab Followed by Alendronate Decreases Fracture Risk in Women With Osteoporosis

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In postmenopausal women at high risk for fracture, treatment with romosozumab for 12 months, followed by alendronate, was associated with significantly fewer hip fractures than treatment with alendronate alone.

Systemic Corticosteroid Use May Increase Fracture Risk in Pediatric Asthma

Systemic Corticosteroid Use May Increase Fracture Risk in Pediatric Asthma

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Increased odds of fractures in pediatric patients with asthma may be associated with systemic corticosteroid use, but not with inhaled corticosteroid use.

Trabecular Bone Morphology Changes May Predict Bone Strength in Girls

Trabecular Bone Morphology Changes May Predict Bone Strength in Girls

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Study investigated the correlations between age and body composition with trabecular morphology in a cohort of healthy girls age 9 to 18.

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

Fracture Risk in Postmenopausal Women With Osteoporosis May Improve With Growth Hormone Therapy

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A recent literature review and meta-analysis indicates that growth hormone therapy may reduce the risk for fracture in patients with osteoporosis.

Calcium, Vitamin D Supplements Do Not Reduce Fracture Risk in Older Adults

Calcium, Vitamin D Supplements Do Not Reduce Fracture Risk in Older Adults

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New findings do not support routine vitamin D and calcium supplementation in community-dwelling older adults for lowering the incidence of osteoporosis-related fractures.

Prevention of Bone Mineral Density Loss Needed in Epilepsy

Prevention of Bone Mineral Density Loss Needed in Epilepsy

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Researchers conducted a long-term follow-up study to determine whether BMD loss, osteoporosis, and fractures were successfully treated or prevented in an urban population of patients with epilepsy and reduced bone density.

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

Teriparatide More Effective Than Risedronate in Osteoporotic Fractures

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Teriparatide is associated with a lower risk for new vertebral and clinical fractures compared with risedronate in post-menopausal women being treated for severe osteoporosis.

Insulin Associated With BMD Loss at Femoral Neck in Women With T2D

Insulin Associated With BMD Loss at Femoral Neck in Women With T2D

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Bone mineral density was evaluated annually of the lumbar spine and femoral neck.

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

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The association between alendronate use and nonvertebral fracture was strongest in patients who received high doses of glucocorticoid.

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

In a randomized multidose trial, single doses of zoledronate (1-5 mg) prolonged antiresorptive activity ≥3 years in postmenopausal women with osteopenia.

Higher Prevalence of Sarcopenic Obesity in Osteoarthritis Than Rheumatoid Arthritis

Higher Prevalence of Sarcopenic Obesity in Osteoarthritis Than Rheumatoid Arthritis

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The prevalence of sarcopenia — particularly in combination with ostepenia — increases with age, and sarcopenic obesity may be underrecognized, despite its impact in patients with rheumatic diseases.

Risks Associated With Denosumab Discontinuation

Risks Associated With Denosumab Discontinuation

Risk of vertebral fractures may be increased with discontinuation of denosumab therapy.

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

The task force recommends screening for osteoporosis with bone measurement testing to prevent osteoporotic fractures in women ≥65 years and postmenopausal women.

Poorly Controlled Rheumatoid Arthritis Increases T2D Risk

Poorly Controlled Rheumatoid Arthritis Increases T2D Risk

Type 2 diabetes is significantly underdiagnosed and undertreated in patients with rheumatoid arthritis.

Examining the Relationship Between Linear Growth and Bone Accrual in Children and Adolescents

Examining the Relationship Between Linear Growth and Bone Accrual in Children and Adolescents

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Height gains "substantially outpaced" bone mineral content gains during childhood, potentially leading to increased fracture risk.

BMD and Physical Activity: Examining the Relationship in Class III Obesity

BMD and Physical Activity: Examining the Relationship in Class III Obesity

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Both intensity of physical activity and time spent active can explain variability in femoral neck BMD in people with class III obesity.

New Bone Density Assessment Effectively Predicts Fracture Risk in Children

New Bone Density Assessment Effectively Predicts Fracture Risk in Children

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A femoral stress index assessment evaluates fracture risk in children as effectively as femoral and total body bone mineral density.

Safety, Efficacy of Burosumab vs Placebo for X-Linked Hypophosphatemia Examined

Safety, Efficacy of Burosumab vs Placebo for X-Linked Hypophosphatemia Examined

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In a double-blind multicenter study, researchers examined the safety and efficacy of burosumab for X-linked hypophosphatemia.

Protective Effect of Hypoxia on Bone Health in Menopausal Women

Protective Effect of Hypoxia on Bone Health in Menopausal Women

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Intermittent hypoxia in obstructive sleep apnea was found to decrease the chances of bone health decline in menopausal women.

Can Anxiety or Depression Determine Low BMD in Patients With Anorexia?

Can Anxiety or Depression Determine Low BMD in Patients With Anorexia?

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Both anxiety and depression scores are associated with low BMD.

Single BMD, Fracture History Predicts Long-Term Fracture Risk in Older Women

Single BMD, Fracture History Predicts Long-Term Fracture Risk in Older Women

A single bone mineral density measure and fracture history can predict long-term fracture risk in older women.

K-Postn Assay New Tool to Assess Fracture Risk in Postmenopausal Women

K-Postn Assay New Tool to Assess Fracture Risk in Postmenopausal Women

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According to a study published in the Journal of Bone and Mineral Research, researchers hypothesized that serum K-Postn levels may be able to predict low-trauma fractures.

Effects of Cross-Sex Hormone Therapy on BMD of Transgender People

Effects of Cross-Sex Hormone Therapy on BMD of Transgender People

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The effect of 1 year of cross-sex hormone therapy on bone mineral density was examined in transgender men and women.

Vitamin B, Folic Acid Effect on Fracture Risk in Women With CV Disease

Vitamin B, Folic Acid Effect on Fracture Risk in Women With CV Disease

Daily supplementation with B vitamins and folic acid does not affect fracture risk for women with preexisting CV disease.

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

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Researchers examined the benefits and risks associated with delaying ART initiation to slow bone mineral density loss.

BMD of Femoral Neck Declines Twice as Fast in HIV-Infected Women

BMD of Femoral Neck Declines Twice as Fast in HIV-Infected Women

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Bone mineral density of the femoral neck, a significant predictor of fracture risk, declined nearly twice as quickly in HIV-infected women compared with HIV-infected men.

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