Bone Metabolism

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Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

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Insulin Associated With BMD Loss at Femoral Neck in Women With T2D

Insulin Associated With BMD Loss at Femoral Neck in Women With T2D

Bone mineral density was evaluated annually of the lumbar spine and femoral neck.

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

Alendronate With Glucocorticoids Lowers Nonvertebral Fracture Risk

The association between alendronate use and nonvertebral fracture was strongest in patients who received high doses of glucocorticoid.

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

Prolonged Antiresorptive Activity With Zoledronate in Postmenopausal Osteopenia

In a randomized multidose trial, single doses of zoledronate (1-5 mg) prolonged antiresorptive activity ≥3 years in postmenopausal women with osteopenia.

Higher Prevalence of Sarcopenic Obesity in Osteoarthritis Than Rheumatoid Arthritis

Higher Prevalence of Sarcopenic Obesity in Osteoarthritis Than Rheumatoid Arthritis

The prevalence of sarcopenia — particularly in combination with ostepenia — increases with age, and sarcopenic obesity may be underrecognized, despite its impact in patients with rheumatic diseases.

Risks Associated With Denosumab Discontinuation

Risks Associated With Denosumab Discontinuation

Risk of vertebral fractures may be increased with discontinuation of denosumab therapy.

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

USPSTF: Screening Recommendations Updated for Preventing Osteoporotic Fractures

The task force recommends screening for osteoporosis with bone measurement testing to prevent osteoporotic fractures in women ≥65 years and postmenopausal women.

Predicting Hypocalcemia in Children Following Thyroidectomy: Is PTH Level Useful?

Predicting Hypocalcemia in Children Following Thyroidectomy: Is PTH Level Useful?

While parathyroid hormone levels may be used to anticipate calcium decline, a "normal" PTH level does not always correctly predict postoperative calcium level.

Update on Vitamin D and Calcium Supplements for Reducing Fracture Risk

Update on Vitamin D and Calcium Supplements for Reducing Fracture Risk

The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

Poorly Controlled Rheumatoid Arthritis Increases T2D Risk

Poorly Controlled Rheumatoid Arthritis Increases T2D Risk

Type 2 diabetes is significantly underdiagnosed and undertreated in patients with rheumatoid arthritis.

Examining the Relationship Between Linear Growth and Bone Accrual in Children and Adolescents

Examining the Relationship Between Linear Growth and Bone Accrual in Children and Adolescents

Height gains "substantially outpaced" bone mineral content gains during childhood, potentially leading to increased fracture risk.

Romosozumab Plus Alendronate Reduces Fracture Risk in Postmenopausal Osteoporosis

Romosozumab Plus Alendronate Reduces Fracture Risk in Postmenopausal Osteoporosis

Risk of new vertebral fracture was reduced among women int he romosozumab-to-alendronate group vs those who took alendronate alone.

BMD and Physical Activity: Examining the Relationship in Class III Obesity

BMD and Physical Activity: Examining the Relationship in Class III Obesity

Both intensity of physical activity and time spent active can explain variability in femoral neck BMD in people with class III obesity.

New Bone Density Assessment Effectively Predicts Fracture Risk in Children

New Bone Density Assessment Effectively Predicts Fracture Risk in Children

A femoral stress index assessment evaluates fracture risk in children as effectively as femoral and total body bone mineral density.

Safety, Efficacy of Burosumab vs Placebo for X-Linked Hypophosphatemia Examined

Safety, Efficacy of Burosumab vs Placebo for X-Linked Hypophosphatemia Examined

In a double-blind multicenter study, researchers examined the safety and efficacy of burosumab for X-linked hypophosphatemia.

Can Anxiety or Depression Determine Low BMD in Patients With Anorexia?

Can Anxiety or Depression Determine Low BMD in Patients With Anorexia?

Both anxiety and depression scores are associated with low BMD.

Protective Effect of Hypoxia on Bone Health in Menopausal Women

Protective Effect of Hypoxia on Bone Health in Menopausal Women

Intermittent hypoxia in obstructive sleep apnea was found to decrease the chances of bone health decline in menopausal women.

Single BMD, Fracture History Predicts Long-Term Fracture Risk in Older Women

Single BMD, Fracture History Predicts Long-Term Fracture Risk in Older Women

A single bone mineral density measure and fracture history can predict long-term fracture risk in older women.

K-Postn Assay New Tool to Assess Fracture Risk in Postmenopausal Women

K-Postn Assay New Tool to Assess Fracture Risk in Postmenopausal Women

According to a study published in the Journal of Bone and Mineral Research, researchers hypothesized that serum K-Postn levels may be able to predict low-trauma fractures.

Effects of Cross-Sex Hormone Therapy on BMD of Transgender People

Effects of Cross-Sex Hormone Therapy on BMD of Transgender People

The effect of 1 year of cross-sex hormone therapy on bone mineral density was examined in transgender men and women.

Vitamin B, Folic Acid Effect on Fracture Risk in Women With CV Disease

Vitamin B, Folic Acid Effect on Fracture Risk in Women With CV Disease

Daily supplementation with B vitamins and folic acid does not affect fracture risk for women with preexisting CV disease.

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

Researchers examined the benefits and risks associated with delaying ART initiation to slow bone mineral density loss.

BMD of Femoral Neck Declines Twice as Fast in HIV-Infected Women

BMD of Femoral Neck Declines Twice as Fast in HIV-Infected Women

Bone mineral density of the femoral neck, a significant predictor of fracture risk, declined nearly twice as quickly in HIV-infected women compared with HIV-infected men.

Managing Osteoporosis With Type 2 Diabetes: An Expert Opinion

Managing Osteoporosis With Type 2 Diabetes: An Expert Opinion

Researchers conducted a systematic review of available literature to create a guide for optimal management of patients with type 2 diabetes and osteoporosis.

FDA Requests Additional Data in Romosozumab Biologics License Application

FDA Requests Additional Data in Romosozumab Biologics License Application

The FDA has requested data from 2 additional phase 3 clinical trials analyzing the safety and effectiveness of romosozumab, Amgen, Inc. and UCB's joint osteoporosis drug.

Bone Mineral Density Decline With Immediate Antiretroviral Tx in HIV

Bone Mineral Density Decline With Immediate Antiretroviral Tx in HIV

Changes in bone mineral density at 1 year were similar in the immediate and delayed ART groups.

Parathyroidectomy for Secondary, Tertiary Hyperparathyroidism Increases Morbidity and Mortality

Parathyroidectomy for Secondary, Tertiary Hyperparathyroidism Increases Morbidity and Mortality

After parathyroidectomy, morbidity and mortality rates were considerably higher in patients with secondary and tertiary vs primary hyperparathyroidism.

Does Sedative Use Increase Repeat Fall Risk?

Does Sedative Use Increase Repeat Fall Risk?

Daytime sleepiness and poor quality of sleep affect recurrent fall risk in the elderly.

Hand Osteoarthritis and Type 1 Diabetes: Is There A Connection?

Hand Osteoarthritis and Type 1 Diabetes: Is There A Connection?

Hand pain, disability, and stiffness were common in long-term type 1 diabetes.

Colecalciferol Did Not Reduce Fracture or Fall Risks

Colecalciferol Did Not Reduce Fracture or Fall Risks

Healthy middle-age patients who took colecalciferol did not have a reduced risk for fall or fracture.

Fracture Risk Cut With Low Level of Physical Activity

Fracture Risk Cut With Low Level of Physical Activity

Twenty minutes per day of walking or bicycling were associated with a lower rate of fracture.

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