Bone Metabolism

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BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

BMD Loss Slowed With Delayed Antiretroviral Therapy in HIV

Researchers examined the benefits and risks associated with delaying ART initiation to slow bone mineral density loss.

BMD of Femoral Neck Declines Twice as Fast in HIV-Infected Women

BMD of Femoral Neck Declines Twice as Fast in HIV-Infected Women

Bone mineral density of the femoral neck, a significant predictor of fracture risk, declined nearly twice as quickly in HIV-infected women compared with HIV-infected men.

Managing Osteoporosis With Type 2 Diabetes: An Expert Opinion

Managing Osteoporosis With Type 2 Diabetes: An Expert Opinion

Researchers conducted a systematic review of available literature to create a guide for optimal management of patients with type 2 diabetes and osteoporosis.

FDA Requests Additional Data in Romosozumab Biologics License Application

FDA Requests Additional Data in Romosozumab Biologics License Application

The FDA has requested data from 2 additional phase 3 clinical trials analyzing the safety and effectiveness of romosozumab, Amgen, Inc. and UCB's joint osteoporosis drug.

Bone Mineral Density Decline With Immediate Antiretroviral Tx in HIV

Bone Mineral Density Decline With Immediate Antiretroviral Tx in HIV

Changes in bone mineral density at 1 year were similar in the immediate and delayed ART groups.

Parathyroidectomy for Secondary, Tertiary Hyperparathyroidism Increases Morbidity and Mortality

Parathyroidectomy for Secondary, Tertiary Hyperparathyroidism Increases Morbidity and Mortality

After parathyroidectomy, morbidity and mortality rates were considerably higher in patients with secondary and tertiary vs primary hyperparathyroidism.

Does Sedative Use Increase Repeat Fall Risk?

Does Sedative Use Increase Repeat Fall Risk?

Daytime sleepiness and poor quality of sleep affect recurrent fall risk in the elderly.

Hand Osteoarthritis and Type 1 Diabetes: Is There A Connection?

Hand Osteoarthritis and Type 1 Diabetes: Is There A Connection?

Hand pain, disability, and stiffness were common in long-term type 1 diabetes.

Colecalciferol Did Not Reduce Fracture or Fall Risks

Colecalciferol Did Not Reduce Fracture or Fall Risks

Healthy middle-age patients who took colecalciferol did not have a reduced risk for fall or fracture.

Fracture Risk Cut With Low Level of Physical Activity

Fracture Risk Cut With Low Level of Physical Activity

Twenty minutes per day of walking or bicycling were associated with a lower rate of fracture.

Examining the Relationship Between Weight Loss and Knee Degeneration

Examining the Relationship Between Weight Loss and Knee Degeneration

Participants who lost between 5% and 10% or more than 10% of their body weight slowed knee joint degeneration, compared to those who maintained their current weight.

Ertugliflozin Plus Metformin Improves Glycemic Control in Type 2 Diabetes

Ertugliflozin Plus Metformin Improves Glycemic Control in Type 2 Diabetes

A randomized double-blind trial examined the safety and efficacy of ertugliflozin plus metformin for inadequately controlled type 2 diabetes.

Sleeping Pills and Fracture Risk: Is There A Link?

Sleeping Pills and Fracture Risk: Is There A Link?

A 2.5 times higher fracture risk was noted among elderly patients taking sleeping pills.

Fracture Risk Decreases, Bone Mineral Density Increases With Long-Term Denosumab

Fracture Risk Decreases, Bone Mineral Density Increases With Long-Term Denosumab

Long-term denosumab increased bone mineral density in postmenopausal women.

ACOG Guidelines Urge Screening for Female Athlete Triad

ACOG Guidelines Urge Screening for Female Athlete Triad

The female athlete triad includes low energy availability, menstrual dysfunction, and low bone density.

Increasing Bone Mineral Density in Older Men

Increasing Bone Mineral Density in Older Men

After 1 year of therapy, men who underwent testosterone therapy experienced improvement in bone mineral density and mood.

ACP: Updated Osteoporosis Treatment Guidelines

ACP: Updated Osteoporosis Treatment Guidelines

An update to the 2008 ACP osteoporosis treatment guidelines focuses on treating low bone density and osteoporosis in an effort to prevent fractures.

Osteoporosis, Fracture Risk Elevated With Tuberculosis

Osteoporosis, Fracture Risk Elevated With Tuberculosis

Tuberculosis was identified as an independent risk factor associated with incident osteoporosis.

Oral Contraceptives May Reduce Fracture Risk

Oral Contraceptives May Reduce Fracture Risk

Women who had taken oral contraceptives for more than 5 years had the lowest risk for fracture.

Osteoporosis Treatment Approaches in Women vs Men

Osteoporosis Treatment Approaches in Women vs Men

A review of osteoporosis diagnosis, treatment, and management in both men and women.

Does Aerobic-Resistance Exercise Benefit Seniors With Obesity?

Does Aerobic-Resistance Exercise Benefit Seniors With Obesity?

At 6 months of exercise intervention, physical performance test scores increased 21% in the combination exercise group, while scores in the control group remained largely the same.

Benefits of Osteoporosis Pharmacotherapy Misunderstood Among Older Women

Benefits of Osteoporosis Pharmacotherapy Misunderstood Among Older Women

Eighty-four percent of survey respondents did not undergo osteoporosis pharmacotherapy following an osteoporosis-related fracture.

FDA Approves Abaloparatide for Fragility Fracture in Postmenopausal Women With Osteoporosis

FDA Approves Abaloparatide for Fragility Fracture in Postmenopausal Women With Osteoporosis

Tymlos approval was based on the results of the ACTIVE and ACTIVExtension trials.

Denosumab-induced Prolonged Hypocalcemia: A Case Study

Denosumab-induced Prolonged Hypocalcemia: A Case Study

Investigators examined an 83-year-old male patient who developed severe hypocalcemia induced by denosumab.

HIV-Induced Osteoporosis Detected Using Bone Ultrasonography

HIV-Induced Osteoporosis Detected Using Bone Ultrasonography

Bone ultrasonography is able to detect tenofovir-induced bone loss in patients with HIV.

Bone Mineral Density Changes Related to Adrenal Incidentalomas in Menopausal Women

Bone Mineral Density Changes Related to Adrenal Incidentalomas in Menopausal Women

After 24 months, bone mineral density was statistically different from baseline.

Physical Activity, Sedentary Time and Bone Strength Association in Teens

Physical Activity, Sedentary Time and Bone Strength Association in Teens

Moderate-to-vigorous physical activity was found to be an independent predictor of bone strength in adolescents.

Long-Term Safety of Denosumab in Postmenopausal Osteoperosis

Long-Term Safety of Denosumab in Postmenopausal Osteoperosis

The most common adverse events associated with long-term denosumab use were back, musculoskeletal, or extremity pain, hypercholesterolemia, and cystis.

Osteoporosis Care Quality Most Consistently Predicted By Primary Care

Osteoporosis Care Quality Most Consistently Predicted By Primary Care

The most important predictor for use of osteoporosis care was receiving primary care services within 6 months following hip fracture.

Is Normal Basal Bone Metabolism Vitamin D-Dependent in Postmenopausal Women With T2D?

Is Normal Basal Bone Metabolism Vitamin D-Dependent in Postmenopausal Women With T2D?

Findings in postmenopausal women with T2DM; correlations prominent in those with higher 25(OH)D

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