Bone Metabolism

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Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

Updated Recommendation on Vit D and Calcium for Reducing Fx Risk

The USPSTF commissioned a systematic evidence review on vitamin D, calcium, and combined supplementation for the primary prevention of fractures in community-dwelling adults.

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An Intermediary Role for Insulin Resistance in the Adipose-Bone Mass Relationship in Adolescents

An Intermediary Role for Insulin Resistance in the Adipose-Bone Mass Relationship in Adolescents

Insulin resistance may play an intermediary role in the relationship between adiposity and lumbar spine bone mass in adolescents.

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia Lead Levels Associated With Risk for Resistant Hypertension

Tibia lead levels are associated with resistant-hypertension.

Childhood Participation in Sports Linked to Higher Adult Bone Mass

Childhood Participation in Sports Linked to Higher Adult Bone Mass

Children who are consistent sport participators have greater bone mineral content (BMC) at age 20 years.

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

Vitamin D Supplementation Has No Effect on Musculoskeletal Health

There is little justification for the use of vitamin D supplements to maintain or improve musculoskeletal health.

Bone-Derived Factors in the Treatment of Diabetes

Bone-Derived Factors in the Treatment of Diabetes

A growing body of research highlights the important role of bone in glucose metabolism.

Zoledronate Lowers Fracture Risk in Women With Osteopenia

Zoledronate Lowers Fracture Risk in Women With Osteopenia

The risk for fragility fractures is significantly lower in women with osteopenia who receive zoledronate than in those who receive placebo.

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

Diabetes Associated With Elevated Risk for Arthritis, Osteoporosis

Osteoarthritis was the most common form of arthritis in patients with diabetes but rheumatoid arthritis had the most pronounced association with diabetes.

Roux-en-Y Gastric Bypass Surgery Associated With Long-Term Bone Loss

Roux-en-Y Gastric Bypass Surgery Associated With Long-Term Bone Loss

Roux-en-Y gastric bypass is associated with bone density and skeletal microarchitecture deterioration, leading to substantial cumulative bone loss.

Incident Vertebral Fracture Risk in Former, Current Smokers With or Without COPD

Incident Vertebral Fracture Risk in Former, Current Smokers With or Without COPD

Bone attenuation was found to be an independent determinant for vertebral fractures in former smokers with and without chronic obstructive pulmonary disease.

Bone Mineral Density Improved With Intravenous Ibandronate in Osteoporosis

Bone Mineral Density Improved With Intravenous Ibandronate in Osteoporosis

Investigators assessed the effectiveness of intravenous ibandronate on bone mineral density in patients with osteoporosis who did not respond to oral bisphosphonates.

Glucocorticoids Linked to Significant Bone Deficit in Pediatric Crohn Disease

Glucocorticoids Linked to Significant Bone Deficit in Pediatric Crohn Disease

Glucocorticoid therapy was linked to significant bone deficits across multiple axial sites, regardless of disease activity.

MicroRNAs Linked to Increased Cortical Bone Porosity in Postmenopausal Women With History of Fracture

MicroRNAs Linked to Increased Cortical Bone Porosity in Postmenopausal Women With History of Fracture

Findings suggest potential pathomechanistic links between miRNAs and cortical porosity. .

Effects of Vitamin D3 Treatment on Bone Strength in Postmenopausal Women

Effects of Vitamin D3 Treatment on Bone Strength in Postmenopausal Women

Investigators sought to determine the effects of vitamin D3 supplementation in postmenopausal women with low serum 25(OH)D and high parathyroid hormone levels.

Early Life Exposures Affect Bone Density in Young Adulthood

Early Life Exposures Affect Bone Density in Young Adulthood

Early life exposures, such as maternal smoking and breastfeeding, may have effects on bone mineral density in young adulthood.

Drug Holidays May Reduce Risk for Atypical Femur Fracture

Drug Holidays May Reduce Risk for Atypical Femur Fracture

Bisphosphonate holidays of 3 to 5 years have been recommended as a means of achieving the antifracture benefit of the medication.

Fifteen Genetic Determinants of Fracture Identified

Fifteen Genetic Determinants of Fracture Identified

Fifteen genetic determinants of fracture, which are also associated with bone mineral density, have been identified.

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

Poststroke Statin Therapy Associated With Lower Risk for Osteoporosis, Fractures

A variety of underlying mechanisms may be attributed to the role of statins in preventing bone-related disorders.

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

Advanced Glycation End Products and esRAGE Predict Hip Fractures in Older Men

Investigators assess whether circulating advanced glycation end products and esRAGE were associated with bone turnover and risk for fracture.

The Relationship Between Hip/Knee Osteoarthritis and Risk for Incident Diabetes

The Relationship Between Hip/Knee Osteoarthritis and Risk for Incident Diabetes

Bilateral hip or knee osteoarthritis was significantly associated with a 16% to 25% increased risk for incident diabetes.

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

Influence of Weight Loss, Resistance Training, and Aerobic Training on Bone Health

Investigators assessed the effect of exercise modality during dietary-induced on bone health.

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

Real-World Data Show Reduced Fracture Rates in Teriparatide-Treated Osteoporosis

Rates of incident clinical vertebral fracture, incident nonvertebral fracture, hip fracture, and clinical fractures decreased 6 months after initiation of teriparatide.

Genetic Screening May Predict Osteoporosis, Fracture Risk

Genetic Screening May Predict Osteoporosis, Fracture Risk

Genetic testing may identify individuals with an increased risk for osteoporosis and bone fracture.

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Decreased Osteoporosis Treatment Initiation Observed After Hip Fracture

Researchers observed a reduction in subsequent nonvertebral fracture rates in patients who initiated osteoporosis treatment.

Bone Mineral Density Loss Eventually Stabilizes in Men With Type 1 Diabetes

Bone Mineral Density Loss Eventually Stabilizes in Men With Type 1 Diabetes

Investigators determined that reductions in bone mineral density in men with type 1 diabetes occur early in the course of the disease.

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

HbA1c-Corrected FRAX Score May Better Predict Fracture Risk in Type 2 Diabetes

A corrected HbA1C factor may improve the ability to predict the risk for fracture by the FRAX algorithm in T2D.

Urinary Biomarkers Can Help to Predict Peri-Implant Osteolysis

Urinary Biomarkers Can Help to Predict Peri-Implant Osteolysis

Investigators compared biomarkers in patients who eventually developed radiographic osteolytic lesions to those who did not.

Prednisone, Prednisolone Does Not Adversely Affect Bone Mineral Density in RA

Prednisone, Prednisolone Does Not Adversely Affect Bone Mineral Density in RA

Researchers observed no change in bone mineral density in patients with early and active rheumatoid arthritis who were treated with prednisone or prednisolone vs placebo.

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Effect of Mediterranean Diet Plus Vitamin D3 on Bone Density in Osteoporosis

Investigators examined the effect of consuming a Mediterranean-style diet for 1 year on inflammatory response and bone health in the elderly.

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

New Romosozumab BLA Includes Data from Additional Osteoporosis Trials

Evenity is a bone-forming monoclonal antibody designed to inhibit the activity of sclerostin, which allows the drug to rapidly increase bone formation and reduce bone resorption simultaneously.

Romosozumab: Effective in Men With Osteoporosis

Romosozumab: Effective in Men With Osteoporosis

Romosozumab increased spine and hip bone mineral density after 12 months of treatment.

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