Risk for Death Increased With Osteogenesis Imperfecta
Patients with osteogenesis imperfecta have an elevated risk for death.
(HealthDay News) — Patients with osteogenesis imperfecta have an elevated risk for death, according to a study published in the Journal of Bone and Mineral Research.
Lars Folkestad, MD, from Odense University Hospital in Denmark, and colleagues calculated the risk and cause of death, as well as median survival times, in patients with osteogenesis imperfecta. Data were included from the Danish National Patient Register from 1977 to 2013. Patients with the diagnosis of osteogenesis imperfecta were matched 1:5 with a reference population.
The researchers included data for 687 cases of osteogenesis imperfecta and 3435 reference individuals. During the observation period, 112 patients with osteogenesis imperfecta and 257 persons in the reference population died (all-cause mortality hazard ratio, 2.90).
The median survival time was 72.4 years for males with osteogenesis imperfecta, compared with 81.9 years in the reference population; for females, the corresponding median survival times were 77.4 and 84.5 years. An elevated risk for death from respiratory diseases, gastrointestinal diseases, and trauma was seen for patients with osteogenesis imperfecta.
"Patients with osteogenesis imperfecta had a higher mortality rate throughout their life compared to the general population," the researchers wrote.
Several authors disclosed financial ties to the pharmaceutical industry.