Bone Metabolism Archive
Researchers examined the benefits and risks associated with delaying ART initiation to slow bone mineral density loss.
Bone mineral density of the femoral neck, a significant predictor of fracture risk, declined nearly twice as quickly in HIV-infected women compared with HIV-infected men.
Researchers conducted a systematic review of available literature to create a guide for optimal management of patients with type 2 diabetes and osteoporosis.
The FDA has requested data from 2 additional phase 3 clinical trials analyzing the safety and effectiveness of romosozumab, Amgen, Inc. and UCB's joint osteoporosis drug.
Changes in bone mineral density at 1 year were similar in the immediate and delayed ART groups.
After parathyroidectomy, morbidity and mortality rates were considerably higher in patients with secondary and tertiary vs primary hyperparathyroidism.
Daytime sleepiness and poor quality of sleep affect recurrent fall risk in the elderly.
Hand pain, disability, and stiffness were common in long-term type 1 diabetes.
Healthy middle-age patients who took colecalciferol did not have a reduced risk for fall or fracture.
Twenty minutes per day of walking or bicycling were associated with a lower rate of fracture.
Participants who lost between 5% and 10% or more than 10% of their body weight slowed knee joint degeneration, compared to those who maintained their current weight.
A randomized double-blind trial examined the safety and efficacy of ertugliflozin plus metformin for inadequately controlled type 2 diabetes.
A 2.5 times higher fracture risk was noted among elderly patients taking sleeping pills.
Long-term denosumab increased bone mineral density in postmenopausal women.
The female athlete triad includes low energy availability, menstrual dysfunction, and low bone density.
After 1 year of therapy, men who underwent testosterone therapy experienced improvement in bone mineral density and mood.
An update to the 2008 ACP osteoporosis treatment guidelines focuses on treating low bone density and osteoporosis in an effort to prevent fractures.
Tuberculosis was identified as an independent risk factor associated with incident osteoporosis.
Women who had taken oral contraceptives for more than 5 years had the lowest risk for fracture.
A review of osteoporosis diagnosis, treatment, and management in both men and women.
At 6 months of exercise intervention, physical performance test scores increased 21% in the combination exercise group, while scores in the control group remained largely the same.
Eighty-four percent of survey respondents did not undergo osteoporosis pharmacotherapy following an osteoporosis-related fracture.
Tymlos approval was based on the results of the ACTIVE and ACTIVExtension trials.
Investigators examined an 83-year-old male patient who developed severe hypocalcemia induced by denosumab.
Bone ultrasonography is able to detect tenofovir-induced bone loss in patients with HIV.
After 24 months, bone mineral density was statistically different from baseline.
Moderate-to-vigorous physical activity was found to be an independent predictor of bone strength in adolescents.
The most common adverse events associated with long-term denosumab use were back, musculoskeletal, or extremity pain, hypercholesterolemia, and cystis.
The most important predictor for use of osteoporosis care was receiving primary care services within 6 months following hip fracture.
Findings in postmenopausal women with T2DM; correlations prominent in those with higher 25(OH)D
Researchers compared the efficacy of dual-energy x-ray absorptiometry with lateral x-ray in assessing vertebral fractures.
Fragility fracture risk increased with older age and decreased with higher bone mineral density in patients with type 1 diabetes.
Using dual-energy X-ray absorptiometry for bone age assessment complements traditional radiologic assessment.
Researchers evaluated trabecular bone scores in more than 100 women during either "legs up" or "legs down" dual energy x-ray absorptiometry scans.
Neither DXA-visceral adipose tissue nor android-gynoid fat mass ratios were associated with atherosclerotic cardiovascular disease events.
The Bone Health TeleECHO Clinic helps telementor healthcare professionals and improves osteoporosis care in underserved communities.
Total hip BMD was associated with heart failure risk in black and non-black men, with an interaction by race.
Testosterone treatment improved both bone mineral density and strength in older men.
The effects of repeat doses of antenatal betamethasone were assessed in 185 eligible pediatric patients.
Researchers found that female patients recovering from critical illness respond better to anti-fracture therapy for bone mineral density loss prevention compared with men.
Disease burden associated with hypophosphatasia was analyzed in a population of patients utilizing electronic medical records.
Study examines the predictive value for vertebral fractures of bone mineral density and bone turnover markers after a 5-year drug holiday.
The long-term effects of several hepatitis virus antivirals on various aspects of bone metabolism are unclear.
The risk of developing fracture in postmenopausal women with osteoporosis who discontinued bisphosphonate therapy was evaluated in a retrospective study.
The trabecular bone score may provides an acute, albeit indirect, measurement of bone quality in patients with type 2 diabetes.
Data were collected from the Osteoarthritis Initiative to examine the relationship between knee osteoarthritis and hypertension.
Patients with rheumatoid arthritis (RA) were evaluated at a specialized clinic to determine the relationship between knee osteoarthritis and elevated Disease Activity Scores (DAS28).
Patients taking tenofovir should aim to maximize the phosphorous in their diet.
Ankle fractures presented similar mortality rates between men and women, while other types of fractures had higher mortality rates among men.
Researchers examined the nonvertebral fracture risk in adults with obesity who underwent Roux-en-Y gastric bypass vs adjustable gastric banding.
Incident falls were linked with total testosterone and bioavailable levels of testosterone after adjusting for age and prevalent falls.
Two distinct time trends were observed in initiation of oral bisphosphonates in women after the 2008 updated osteoporosis treatment guidelines.
Younger survivors of thyroid cancer are at increased risk for certain types of health problems later in life.
Patients with psoriatic arthritis or psoriasis had an increased prevalence of osteoporosis risk factors.
Bone Index announced that the Food and Drug Administration (FDA) has granted clearance for the second generation Bindex device model to aid in the diagnosis of osteoporosis.
A prospective cohort study in 66 patients with end-stage renal disease was conducted to determine the link between renal and coronary heart diseases.
Cardiovascular disease, stroke, diabetes, hip and knee replacements, and both behavioral and mental disorders were also more common in the Alzheimer's disease cohort.
Etelcalcetide shows promise for reducing parathyroid hormone in hemodialysis patients with secondary hyperparathyroidism.
According to the National Cancer Institute, there are not enough available data to establish whether taking vitamin D can prevent cancer.
Less frequent dosing with zoledronic acid does not increase fracture risk in patients with bone metastases.
The association between risk for hip fracture and diabetes was attenuated after accounting for mortality risk.
For patients with type 2 diabetes, long-term use of dipeptidyl peptidase-4 (DPP-4) inhibitors is not associated with fracture risk.
Lorraine Fitzpatrick, MD, discusses updated results from the ACTIVE phase 3 clinical trial.
In this week's Handoff, read more about recent FDA approvals, food banks' efforts to improve the healthiness of their donations, and more.
Researchers compared 3 classes of antihypertensive medication to determine hip and pelvic fracture risk in users vs nonusers.
The use of menopausal hormone therapy was associated with improved bone mineral density and better bone microarchitecture.
Nancy E. Lane, MD, professor of medicine, at the University of California at Davis School of Medicine, discusses results from the phase 3 ACTIVE trial.
Increased body mass index (BMI) may have a moderate effect on hand arthritis.
Several factors influence the impact of cholecalciferol supplementation in pregnant women.
Heavy cannabis users have lower bone density compared to cigarette smokers.
Children and teens who used stimulants for attention-deficit/hyperactivity disorder had lower bone mineral content and bone density than nonusers.
Calorie restriction has been shown to increase longevity, but it may also have adverse effects on bone health in postmenopausal women.
Summer levels of serum 25-hydroxyvitamin D are associated with bone mineral density of the total hip.
The American Association of Clinical Endocrinologists (AACE) and the American College of Endocrinology (ACE) announced the publication of new clinical guidelines and an accompanying algorithm to help physicians and other health care professionals with the diagnosis, fracture risk assessment, and treatment of postmenopausal osteoporosis.
Orthogeriatric-led service was the most effective and cost-effective model of care for men and women aged 83 years.
Experts from more than 30 national and international societies have pledged to intensify efforts and collaborate to address the "crisis" in osteoporosis.
Phthalates and bisphenol A metabolites were inversely associated with circulating 25-hydroxyvitamin D levels in adults exposed to these chemicals.
Crosstalk between bone and muscle plays a significant role in exercise adaptation.
The risk for vertebral fracture in women with osteoporosis was significantly lower with romosozumab vs placebo at 12 months.
The combination of calcium, proteins, and probiotics found in yogurt may affect gut microbiota and have a positive effect on bone density.
A decline in Medicare reimbursement for DXA testing is one of the factors to higher-than-expected hip fracture rates.
ew findings from a population-based cohort study suggest that there are small but significant deficits in hip bone mineral density (BMD) cross-sectionally associated with sitting time adjusted for physical activity.
Infants fed soy formula vs breast milk experienced greater bone acquisition during the first year of life.
Genetic predisposition for poor bone tissue quality may be a risk factor for hip fracture.
Brief training sessions several times a week for 2 years improved regional and whole-body bone development in teen girls.
Fracture prediction was more accurate with profiling of bone density-related variants vs clinical risk factors alone.
A modest reduction in risk for fracture was noted with calcium plus vitamin D supplements, but the effect on cardiovascular outcomes was unclear.
The oldest age group experienced the greatest improvements with alendronate, as compared with the younger groups in the study.
Osteoporosis and genomics will be among key highlights at the annual meeting of the American Society for Bone and Mineral Research.
According to results from the TECOS trial, sitagliptin is not linked to an increased risk for fractures in patients with diabetes.
Study reveals 6-fold higher risk of secondary hyperparathyroidism in patients on furosemide vs hydrochlorothiazide.
Optimism is associated with a decreased fall risk and cynical hostility with an increased fall risk for women.
Higher pericardial adipose volumes were associated with increases in calcified atherosclerotic plaque.
Obese women have significantly greater total vitamin D stores than normal-weight women, although the pattern of distribution of the stores is similar.
In postmenopausal women with osteoporosis, an experimental drug appears to reduce the risk of bone fractures better than teriparatide or a placebo.
For postmenopausal women, soy isoflavone supplementation is associated with improvement in bone health.
Use of estrogen-containing contraceptives were linked to significantly higher vitamin D levels.
Patients undergoing bariatric surgery were more likely to fracture than obese or non-obese controls.
An index accounting for both bone formation and resorption may help identify which women may experience faster bone loss during menopause.
Physicians should be aware of the "female athlete triad," which includes amenorrhea, osteoporosis, and disordered eating.
Endocrinology Advisor Articles
- Effect of Sugar-Sweetened Beverages on Obesity Development
- Metformin and PCOS: Improving Menstrual Cycle and Hormone Profiles
- Denosumab May Increase BMD in Women With Primary Hyperparathyroidism
- T2D May Play a Protective Role Against Developing Aortic Diseases
- Risk Factors for Diabetes May Be Identified 20 Years Before Diagnosis
- Metformin Safe in T2D With Moderate to Severe Chronic Kidney Disease
- SGLT2 Inhibitors Show High Cardiovascular- and Renal-Protective Effects in T2D
- Type 2 Diabetes Insulin Initiation: Predictors Identified
- Two New Diabetes Medications Now Available
- Managing Acute Pain in Patients With Severe Obesity
- Risk for Congenital Malformations With Antithyroid Drugs
- Occupational Therapy May Benefit Young Adults With Diabetes
- Weight Loss May Improve Pain in Patients With Obesity
- Prior Authorizations Are Creating a Challenge for Clinicians
- Effect of Biologic DMARDs on Spinal Fracture Risk in Ankylosing Spondylitis