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AURYXIA
Anemias
Hyperphosphatemia
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Drug Name:

AURYXIA Rx

Generic Name and Formulations:
Ferric iron 210mg (equivalent to 1g ferric citrate); tabs.

Company:
Keryx Biopharmaceuticals

Therapeutic Use:

Indications for AURYXIA:

Treatment of iron deficiency anemia in adults with chronic kidney disease not on dialysis.

Adult:

Take with meals. Initially 1 tab three times daily; titrate as needed to achieve hemoglobin target levels; max 12 tabs/day.

Children:

Not established.

Contraindications:

Iron overload syndromes (eg, hemochromatosis).

Warnings/Precautions:

Monitor serum phosphorus. Assess iron parameters (eg, serum ferritin, TSAT) prior to initiation and monitor during therapy. Inflammatory bowel disease. Active GI bleeding. Accidental iron overdose (esp. in children <6yrs); may be fatal. Pregnancy. Nursing mothers.

Interactions:

Concomitant IV iron; may require dose reduction or discontinuation of IV therapy. Give doxycycline at least 1hr before Auryxia. Give ciprofloxacin at least 2hrs before or after Auryxia. Concomitant drugs with narrow therapeutic range; consider monitoring.

Pharmacological Class:

Hematinic.

Adverse Reactions:

Diarrhea, discolored feces, constipation, nausea, vomiting, cough, abdominal pain, hyperkalemia; iron overload.

How Supplied:

Tabs—200

Indications for AURYXIA:

To control serum phosphorus levels in patients with chronic kidney disease on dialysis.

Adult:

Take with meals. Initially 2 tabs three times daily; titrate in decrements or increments of 1–2 tabs daily as needed at 1-week or longer intervals to maintain target levels; max 12 tabs/day.

Children:

Not established.

Contraindications:

Iron overload syndromes (eg, hemochromatosis).

Warnings/Precautions:

Monitor serum phosphorus. Assess iron parameters (eg, serum ferritin, TSAT) prior to initiation and monitor during therapy. Inflammatory bowel disease. Active GI bleeding. Accidental iron overdose (esp. in children <6yrs); may be fatal. Pregnancy. Nursing mothers.

Interactions:

Concomitant IV iron; may require dose reduction or discontinuation of IV therapy. Give doxycycline at least 1hr before Auryxia. Give ciprofloxacin at least 2hrs before or after Auryxia. Concomitant drugs with narrow therapeutic range; consider monitoring.

Pharmacological Class:

Phosphate binder.

Adverse Reactions:

Diarrhea, discolored feces, constipation, nausea, vomiting, cough, abdominal pain, hyperkalemia; iron overload.

How Supplied:

Tabs—200

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