Polycystic Ovary Syndrome Increases Preterm Delivery Risk for Twins
Include PCOS in risk estimation and antenatal follow-up for twin pregnancies.
HealthDay News -- Polycystic ovary syndrome diagnosis is associated with increased risk of preterm delivery in twin pregnancies, according to a study published in BJOG: An International Journal of Obstetrics and Gynaecology.
Tone S. Løvvik, MD, from the Norwegian University of Science and Technology in Trondheim, and colleagues conducted a population-based cohort study in Sweden involving 20,965 women with twin births between 1995 and 2009, of whom 226 had a polycystic ovary syndrome (PCOS) diagnosis. The authors investigated pregnancy and perinatal outcomes for women with and without PCOS.
The researchers found that PCOS diagnosis in twin pregnancy correlated with increased preterm delivery risk (51% vs 43%; risk ratio, 1.18). Risk was particularly elevated for spontaneous preterm delivery (37% vs 28%; RR, 1.3) and very preterm birth (14% vs 8%; RR, 1.62).
Low birth weight occurred more often among twins of PCOS mothers (48% vs 39%; adjusted RR, 1.4). After adjustment for gestational age, this difference did not persist. The risk for cesarean section, pre-eclampsia, low five-minute Apgar score, or perinatal mortality did not differ between the two groups.
"The risk of preterm delivery in twin pregnancies is increased by having a PCOS diagnosis," the researchers wrote. "This should be considered in risk estimation and antenatal follow-up of twin pregnancies."