In Obese Women, Lifestyle Intervention Before Infertility Treatment Not Beneficial

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Lifestyle intervention before infertility treatment did not benefit obese women.
Lifestyle intervention before infertility treatment did not benefit obese women.

(HealthDay News) — A lifestyle intervention preceding infertility treatment does not result in higher rates of vaginal birth among obese infertile women, according to a study published in the New England Journal of Medicine.

Meike A.Q. Mutsaerts, MD, PhD, from the University of Groningen in the Netherlands, and colleagues randomly assigned infertile women with a BMI of 29 kg/m² or more to a 6-month lifestyle intervention preceding 18 months of infertility treatment (289 women) or to a control group with immediate infertility treatment for 24 months (285 women).

The researchers found that the intervention group had a discontinuation rate of 21.8%. The mean weight loss was 4.4 kg and 1.1 kg in the intervention group and control groups, respectively, in intention-to-treat analyses (P<.001). 

The primary outcome of vaginal birth of a healthy singleton at term within 24 months occurred in 27.1% and 35.2% of the intervention and control groups, respectively (rate ratio in the intervention group, 0.77; 95 % CI, 0.60-0.99).

"In obese infertile women, a lifestyle intervention preceding infertility treatment, as compared with prompt infertility treatment, did not result in higher rates of a vaginal birth of a healthy singleton at term within 24 months after randomization," the researchers wrote.

Reference

  1. Mutsaerts MAQ, van Oers AM, Groen H, et al. Randomized Trial of a Lifestyle Program in Obese Infertile Women. N Engl J Med. 2016;374:1942-1953. doi:10.1056/NEJMoa1505297.
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