Androgen and Reproductive Disorders Archive
Researchers found that 3061 postmenopausal women of 61,335 developed invasive breast cancer during a mean follow-up of 11.4 years. Women with weight loss (≥5%) had a significantly lower breast cancer risk than women with stable weight.
Products marketed as selective androgen receptor modulators and sold via the internet frequently contain unapproved drugs and substances, and the amount of active compound often does not match that listed on the label.
There may be other roles of estradiol therapy besides relief from menopause-related symptoms, including limiting effects of stress on working memory.
Guideline was developed under the direction of the Practice Committee of the American Society for Reproductive Medicine.
Underweight women have a significantly greater risk of experiencing early menopause compared with lean or overweight women.
Increased mortality risks were limited to the first post-HT year because increases in risks markedly decreased when the follow-up time was extended over more than 1 year.
Long-term exposure to progestin-only oral contraceptives or to a progestin intrauterine device is associated with a small beneficial effect on pelvic girdle pain.
No other randomized clinical trial of hormone therapy has been large enough to assess a potential modifying effect of age on all-cause mortality, and most previous trials of chronic disease outcomes have focused on older women.
Asthma may increase the likelihood of a woman needing fertility treatments prior to becoming pregnant.
Obese men have lower semen volume, number, concentration, and motility, as well as a higher prevalence of oligospermia and asthenospermia.
Predicted probability of conception was not significantly lower for women with low antimüllerian hormone vs those with normal hormone levels.
Researchers examined the efficacy of FlexibleMIB (ethinylestradiol/drospirenone) vs placebo as therapy for endometriosis-related pain.
While hirsutism may indicate metabolic abnormalities, acne and androgenic alopecia are associated with other clinical hyperandrogenism manifestations.
The newly released guidelines include updated language to reflect DSM-V changes, greater flexibility in treatment, and recommendations for CVD, bone health, and prostate cancer screening.
The Female Sexual Functioning Index was used to assess aspects of sexual function and experience in early postmenopausal women.
High costs associated with in vitro fertilization create barriers to fertility treatments that many cannot overcome.
Hyperandrogenic PCOS is associated with maternal pregnancy complications, including gestational diabetes.
Intrarosa, the first FDA approved local, non-estrogen product for treating dyspareunia, is now available.
Although the updated statement does not change the recommendations outlined in previous treatment guidelines, the authors have added 8 new recommendations based on evidence that has emerged in the interim.
Researchers examined menstrual patterns in 128 patients with either a sports-associated concussion or non-head injury.
A combination of early menstruation with more frequent periods may lower a woman's depression risk.
Patients attending VA clinics may experience variability in testosterone prescribing practices for hypogonadism.
Two studies examined the efficacy of acupuncture therapy for stress incontinence and PCOS, finding mixed results.
Data from a UK cohort were used to examine the relationship between maternal sugar intake levels and pediatric respiratory and atopic outcomes.
Acute decline in ovarian function may contribute to the autoimmunity associated with rheumatoid arthritis.
The North American Menopause Society released updated guidelines for hormone therapy use in women who are postmenopausal.
Gonadotropin-releasing hormone antagonist elagolix demonstrated clinical improvement for women with endometriosis-related pain.
Women with endometriosis who participated in the study expressed alternately being treated with ignorance and being ignored by their clinicians.
Research results indicate that more randomized clinical trials are needed to examine the relationship between hearing loss and oral hormone replacement therapy.
Testosterone has been identified as a "potent inhibitor" of lymphoid cells responsible for producing proteins that lead to lung inflammation.
Data from a systematic review and meta-analysis confirmed a higher risk of anxiety and depression in PCOS, but underlying factors are still unclear.
Serum samples, spirometry, and questionnaire data were collected from nearly 1500 women to determine if menopausal status affected lung function.
Incident falls were linked with total testosterone and bioavailable levels of testosterone after adjusting for age and prevalent falls.
Studies published in JAMA and JAMA Internal Medicine highlight the benefits and risks of treating men for low testosterone.
Severe anxiety was independently associated with poor quality of life in postmenopausal patients.
Data from the Nurses' Health Studies were analyzed to determine if there is a link between seropositive and seronegative rheumatoid arthritis and age of menopause onset.
Researchers have pinpointed harmonized references ranges for total testosterone levels in men.
For women with HIV, anti-Müllerian hormone is associated with age of menopause onset.
Outside of hormone therapy, endocrinologists reported having low confidence in their knowledge about caring for transgender patients.
Women in the menopausal transition and early postmenopause are at higher risk for depressive symptoms and negative mood than those in late postmenopause.
Menopausal status is associated with accelerated lung function decline.
In postmenopausal women taking hormone therapy, risk for death from vascular dementia appeared to be reduced.
An international survey shows that women with polycystic ovary syndrome are dissatisfied with the information they receive and the length of time to diagnosis.
Starting testosterone treatment is associated with an increased risk of venous thromboembolism (VTE), peaking within 6 months and declining thereafter.
Electro-acupuncture appeared to be as effective as paroxetine for improving sleep in breast cancer survivors with hot flashes.
Men treated with implantable testosterone pellets have a statistically significant increase in mean hematocrit, but it is unlikely to be clinically relevant.
The FDA recently approved Intrarosa (prasterone) for moderate to severe pain during sexual intercourse due to menopause.
The use of menopausal hormone therapy was associated with improved bone mineral density and better bone microarchitecture.
In breast cancer patients taking aromatase inhibitors, vaginal testosterone cream and an estradiol vaginal ring are both safe and effective for treating urogenital symptoms.
Women with endometriomas have significantly lower anti-Müllerian hormone values, and surgical excision of endometriomas appears to have temporary detrimental effects on ovarian reserve.
A progestogen-testosterone injection may be an effective contraceptive option for men.
The US Food and Drug Administration has added a new warning to all testosterone product labels regarding potential for abuse and serious adverse events.
Resveratrol decreased levels of adrenal and ovarian androgens in women with polycystic ovary syndrome.
Once-daily testosterone solution 2% (T-sol) is safe and improves sex drive and energy in men with androgen deficiency.
Women experienced weight loss as well as decreases in ovarian volume and markers of androgen excess.
Half of women treated with acupuncture report a decline in the frequency of menopausal vasomotor symptoms, according to a study published in Menopause.
During menopause, women who experience more hot flashes at night are more likely to experience worsening mood.
Women who enter menopause before age 45 had a 50% greater risk for cardiovascular disease as well as an increased risk for cardiovascular death.
Researchers found increased fat mass and decreased lean mass at 4 weeks of treatment with estrogen and androgen withdrawal, respectively.
Consumption of up to 14 units per week had no effect on fertility for women trying to conceive.
For patients with a history of anorexia nervosa, both BMI and fat percentage can predict resumption of the menstrual cycle.
Once-daily 2% testosterone solution (T-sol) is safe and effective for sex drive and energy in hypogonadal men.
For women with polycystic ovary syndrome (PCOS) seeking infertility treatment, the use of frozen embryos rather than fresh appears to improve the chances for a successful pregnancy.
Patients undergoing fertility treatment often suffer symptoms of depression or anxiety, but few get any formal help.
Soy isoflavones were associated with lower levels of circulating insulin and biological markers of insulin resistance in polycystic ovary syndrome.
Use of estrogen-containing contraceptives were linked to significantly higher vitamin D levels.
African-American women in particular experienced more rapid progression in metabolic syndrome severity during pre- and perimenopausal periods compared to post-menopausal period.
Researchers found sleep apnea and daytime sleepiness were related to sex hormones, but other factors may play a role.
Women who undergo in vitro fertilization (IVF) are not at increased risk of breast cancer, according to a study published in the Journal of the American Medical Association.
Time to pregnancy was longer for couples in which the male partner had higher urinary paracetamol concentrations.
Premenstrual syndrome and premenstrual dysphoric disorder are associated with increased odds of bulimia nervosa, but not with binge-eating disorder.
Researchers identified 4 distinct trajectories of vasomotor symptoms predicted by reproductive hormones, race and ethnicity, BMI, and psychosocial characteristics.
Opportunistic salpingectomy conducted at the time of laparoscopic hysterectomy does not appear to negatively affect ovarian reserve or increase surgical risk.
The diagnosis and management of polycystic ovary syndrome (PCOS) was discussed in a case vignette published in The New England Journal of Medicine.
Men using testosterone gel experienced improvements in sex drive, sexual activity, and erectile function.
A portion of women with polycystic ovary syndrome may experience excess adrenal hormone production.
The review shows modest reductions in frequency of hot flashes and vaginal dryness, but not in night sweats.
Depressive symptoms are associated with reduced fecundability, according to a study published in the American Journal of Obstetrics and Gynecology.
The findings suggest a neuroendocrine vulnerability in women with migraine.
Women may find it easier to resist the urge to smoke after ovulation.
Lifestyle intervention preceding infertility treatment does not increase vaginal birth rates in obese women.
Researchers hypothesized that an altered balance of sex hormones in men with gender identity disorder would increase the risk of MS.
Four randomized controlled trials show benefits for metformin and oral contraceptive pills.
The BRCA1 mutation may speed the aging of a woman's ovaries.
Moderate-quality evidence shows a reduction in the frequency of hot flashes with paroxetine.
Results showed a decreased prevalence of anemia and components of metabolic syndrome after 54 weeks of treatment.
Findings in healthy females who received progesterone or placebo for 7 days.
Researchers observed improvements in climacteric symptoms and quality of life measures.
Health care costs associated with endocrine-disrupting chemicals exceed €1 billion in the European Union.
Researchers concluded that including androstenedione in the diagnosis of biochemical hyperandrogenism led to a prevalence of hyperandrogenic PCOS of more than 80%.
Duration of estrogen deficiency in women with nonalcoholic fatty liver disease may be more likely to have severe fibrosis.
Almost one-quarter of women report lacking interest in sex at 6 months after initiating a new contraceptive method.
More than 20% of women currently using hormone replacement therapy experienced an increase in migraine severity.
Postmenopausal women whose last pregnancy occurred at 40 years of age or older may have a greater risk of hemorrhagic stroke.
Daily topical testosterone restored normal testosterone levels in hypogonadal men
Women 40 to 49 years of age with breast cancer regained ovarian function after chemotherapy with letrozole treatment.
Five US registry-based studies showed that black, Hispanic, and Asian women had lower clinical pregnancy rates after IVF compared with white women.
A continuous schedule was associated with lower recurrence rates for dysmenorrhea.
Exposure to serotonin-norepinephrine reuptake inhibitors in late pregnancy is associated with increased risk for postpartum hemorrhage.
Sedentary lifestyles were common among middle-aged Hispanic women and were also associated with worse menopausal symptoms.
Endocrinology Advisor Articles
- Metformin Safe in T2D With Moderate to Severe Chronic Kidney Disease
- Pregnancy Rates in Women Undergoing IVF With Fresh vs Frozen Embryos
- Effect of Sugar-Sweetened Beverages on Obesity Development
- Increased Risk for Severe Hypoglycemic Events Associated With CV Outcomes
- Osteoporosis Management: Tailoring a Sequenced Treatment Approach
- Metformin Safe in T2D With Moderate to Severe Chronic Kidney Disease
- SGLT2 Inhibitors Show High Cardiovascular- and Renal-Protective Effects in T2D
- Two New Diabetes Medications Now Available
- Managing Acute Pain in Patients With Severe Obesity
- Gestational Diabetes May Increase Risk for Hypertension, Ischemic Heart Disease, T2D
- Evaluating the Longitudinal Effects of Diabetes on Cognition
- Denosumab May Increase BMD in Women With Primary Hyperparathyroidism
- Case Challenge: Obesity and Shortness of Breath in a 52-Year-Old Man
- Diabetes Mortality Trends in Adults With Low eGFR, No Albuminuria
- Patients Report Major Concerns With Physicians