Androgen and Reproductive Disorders Archive

AACE/ACE Updated Position Statement on Menopause

AACE/ACE Updated Position Statement on Menopause

Although the updated statement does not change the recommendations outlined in previous treatment guidelines, the authors have added 8 new recommendations based on evidence that has emerged in the interim.

Causes of Abnormal Menstruation: Sports-Related Concussion and Non-Head Injuries

Causes of Abnormal Menstruation: Sports-Related Concussion and Non-Head Injuries

Researchers examined menstrual patterns in 128 patients with either a sports-associated concussion or non-head injury.

Estrogen Exposure and Depression Risk Examined

Estrogen Exposure and Depression Risk Examined

A combination of early menstruation with more frequent periods may lower a woman's depression risk.

Testosterone Therapy Prescribing Practices in VA Setting

Testosterone Therapy Prescribing Practices in VA Setting

Patients attending VA clinics may experience variability in testosterone prescribing practices for hypogonadism.

Acupuncture Efficacy in Stress Incontinence, PCOS Examined

Acupuncture Efficacy in Stress Incontinence, PCOS Examined

Two studies examined the efficacy of acupuncture therapy for stress incontinence and PCOS, finding mixed results.

Pediatric Respiratory and Atopic Outcomes With Free Sugar Consumption In Pregnancy

Pediatric Respiratory and Atopic Outcomes With Free Sugar Consumption In Pregnancy

Data from a UK cohort were used to examine the relationship between maternal sugar intake levels and pediatric respiratory and atopic outcomes.

Increased RA Risk in Post-Menopause, Early Post-Menopause

Increased RA Risk in Post-Menopause, Early Post-Menopause

Acute decline in ovarian function may contribute to the autoimmunity associated with rheumatoid arthritis.

North American Menopause Society Releases New Guidelines for Hormone Therapy

North American Menopause Society Releases New Guidelines for Hormone Therapy

The North American Menopause Society released updated guidelines for hormone therapy use in women who are postmenopausal.

Elagolix Relieves Short-Term Menstrual Pain, Dysmenorrhea in Endometriosis

Elagolix Relieves Short-Term Menstrual Pain, Dysmenorrhea in Endometriosis

Gonadotropin-releasing hormone antagonist elagolix demonstrated clinical improvement for women with endometriosis-related pain.

Dual Experiences in Endometriosis Health Care

Dual Experiences in Endometriosis Health Care

Women with endometriosis who participated in the study expressed alternately being treated with ignorance and being ignored by their clinicians.

Oral HRT Increases Postmenopausal Hearing Loss Risk

Oral HRT Increases Postmenopausal Hearing Loss Risk

Research results indicate that more randomized clinical trials are needed to examine the relationship between hearing loss and oral hormone replacement therapy.

Testosterone May Explain Gender Disparity in Rates of Asthma

Testosterone May Explain Gender Disparity in Rates of Asthma

Testosterone has been identified as a "potent inhibitor" of lymphoid cells responsible for producing proteins that lead to lung inflammation.

Does PCOS Increase Depression and Anxiety Symptoms?

Does PCOS Increase Depression and Anxiety Symptoms?

Data from a systematic review and meta-analysis confirmed a higher risk of anxiety and depression in PCOS, but underlying factors are still unclear.

Decline in Lung Function Linked to Menopausal Status

Decline in Lung Function Linked to Menopausal Status

Serum samples, spirometry, and questionnaire data were collected from nearly 1500 women to determine if menopausal status affected lung function.

Older Men With Low Total, Bioavailable Testosterone at Increased Risk for Falls

Older Men With Low Total, Bioavailable Testosterone at Increased Risk for Falls

Incident falls were linked with total testosterone and bioavailable levels of testosterone after adjusting for age and prevalent falls.

JAMA: Testosterone Trial Results Highlight Benefits and Risk of Testosterone Treatment

JAMA: Testosterone Trial Results Highlight Benefits and Risk of Testosterone Treatment

Studies published in JAMA and JAMA Internal Medicine highlight the benefits and risks of treating men for low testosterone.

Postmenopausal Anxiety Linked to Severe Quality-of-Life Impairment

Postmenopausal Anxiety Linked to Severe Quality-of-Life Impairment

Severe anxiety was independently associated with poor quality of life in postmenopausal patients.

Early Menopause Tied to Rheumatoid Arthritis Risk

Early Menopause Tied to Rheumatoid Arthritis Risk

Data from the Nurses' Health Studies were analyzed to determine if there is a link between seropositive and seronegative rheumatoid arthritis and age of menopause onset.

Harmonized Testosterone Reference Ranges Established for Men

Harmonized Testosterone Reference Ranges Established for Men

Researchers have pinpointed harmonized references ranges for total testosterone levels in men.

Menopause Predicted by Anti-Müllerian Hormone in HIV

Menopause Predicted by Anti-Müllerian Hormone in HIV

For women with HIV, anti-Müllerian hormone is associated with age of menopause onset.

Endocrinologists Need More Training in Transgender Care

Endocrinologists Need More Training in Transgender Care

Outside of hormone therapy, endocrinologists reported having low confidence in their knowledge about caring for transgender patients.

Aging vs Menopausal Status as a Predictor of Depression, Negative Mood

Aging vs Menopausal Status as a Predictor of Depression, Negative Mood

Women in the menopausal transition and early postmenopause are at higher risk for depressive symptoms and negative mood than those in late postmenopause.

Menopause Tied to Faster Decline in Lung Function

Menopause Tied to Faster Decline in Lung Function

Menopausal status is associated with accelerated lung function decline.

Hormone Therapy Linked to Reduced Risk for Mortality From Vascular Dementia

Hormone Therapy Linked to Reduced Risk for Mortality From Vascular Dementia

In postmenopausal women taking hormone therapy, risk for death from vascular dementia appeared to be reduced.

Survey: Women Dissatisfied With Diagnosis of Polycystic Ovary Syndrome

Survey: Women Dissatisfied With Diagnosis of Polycystic Ovary Syndrome

An international survey shows that women with polycystic ovary syndrome are dissatisfied with the information they receive and the length of time to diagnosis.

Venous Thromboembolism Risk Higher in Men Starting Testosterone Therapy

Venous Thromboembolism Risk Higher in Men Starting Testosterone Therapy

Starting testosterone treatment is associated with an increased risk of venous thromboembolism (VTE), peaking within 6 months and declining thereafter.

Can Electro-Acupuncture Alleviate Sleep Disturbances in Breast Cancer Survivors?

Can Electro-Acupuncture Alleviate Sleep Disturbances in Breast Cancer Survivors?

Electro-acupuncture appeared to be as effective as paroxetine for improving sleep in breast cancer survivors with hot flashes.

Implantable Testosterone Pellets Associated With Small Hematocrit Increase

Implantable Testosterone Pellets Associated With Small Hematocrit Increase

Men treated with implantable testosterone pellets have a statistically significant increase in mean hematocrit, but it is unlikely to be clinically relevant.

FDA Green-lights Intrarosa for Dsypareunia in Menopause

FDA Green-lights Intrarosa for Dsypareunia in Menopause

The FDA recently approved Intrarosa (prasterone) for moderate to severe pain during sexual intercourse due to menopause.

Bone Health Improved With Menopausal Hormone Therapy

Bone Health Improved With Menopausal Hormone Therapy

The use of menopausal hormone therapy was associated with improved bone mineral density and better bone microarchitecture.

Safety, Efficacy of Vaginal Testosterone Cream, Estradiol Vaginal Ring in Breast Cancer

Safety, Efficacy of Vaginal Testosterone Cream, Estradiol Vaginal Ring in Breast Cancer

In breast cancer patients taking aromatase inhibitors, vaginal testosterone cream and an estradiol vaginal ring are both safe and effective for treating urogenital symptoms.

Endometriomas Linked to Lower Anti-Müllerian Hormone Values

Endometriomas Linked to Lower Anti-Müllerian Hormone Values

Women with endometriomas have significantly lower anti-Müllerian hormone values, and surgical excision of endometriomas appears to have temporary detrimental effects on ovarian reserve.

Birth Control Injections for Men May Prevent Pregnancy

Birth Control Injections for Men May Prevent Pregnancy

A progestogen-testosterone injection may be an effective contraceptive option for men.

FDA Adds New Warning to All Testosterone Products

FDA Adds New Warning to All Testosterone Products

The US Food and Drug Administration has added a new warning to all testosterone product labels regarding potential for abuse and serious adverse events.

Resveratrol May Address Hormonal Imbalance in Polycystic Ovary Syndrome

Resveratrol May Address Hormonal Imbalance in Polycystic Ovary Syndrome

Resveratrol decreased levels of adrenal and ovarian androgens in women with polycystic ovary syndrome.

Once-Daily Testosterone Solution Beneficial in Androgen Deficiency

Once-Daily Testosterone Solution Beneficial in Androgen Deficiency

Once-daily testosterone solution 2% (T-sol) is safe and improves sex drive and energy in men with androgen deficiency.

Bariatric Surgery Beneficial in Polycystic Ovary Syndrome

Bariatric Surgery Beneficial in Polycystic Ovary Syndrome

Women experienced weight loss as well as decreases in ovarian volume and markers of androgen excess.

Acupuncture May Decrease Menopausal Vasomotor Symptoms

Acupuncture May Decrease Menopausal Vasomotor Symptoms

Half of women treated with acupuncture report a decline in the frequency of menopausal vasomotor symptoms, according to a study published in Menopause.

Nighttime Hot Flashes Associated With Mild Depression

Nighttime Hot Flashes Associated With Mild Depression

During menopause, women who experience more hot flashes at night are more likely to experience worsening mood.

Heart Disease, Mortality Risk Up With Early Menopause

Heart Disease, Mortality Risk Up With Early Menopause

Women who enter menopause before age 45 had a 50% greater risk for cardiovascular disease as well as an increased risk for cardiovascular death.

Short-Term Sex Steroid Withdrawal in Men Adversely Affects Body Composition

Short-Term Sex Steroid Withdrawal in Men Adversely Affects Body Composition

Researchers found increased fat mass and decreased lean mass at 4 weeks of treatment with estrogen and androgen withdrawal, respectively.

Moderate Alcohol Consumption Does Not Affect Fertility in Women

Moderate Alcohol Consumption Does Not Affect Fertility in Women

Consumption of up to 14 units per week had no effect on fertility for women trying to conceive.

Menstrual Cycle Resumption After Anorexia Predicted by BMI, Fat Percentage

Menstrual Cycle Resumption After Anorexia Predicted by BMI, Fat Percentage

For patients with a history of anorexia nervosa, both BMI and fat percentage can predict resumption of the menstrual cycle.

Testosterone Solution Found Safe, Effective for Hypogonadal Men

Testosterone Solution Found Safe, Effective for Hypogonadal Men

Once-daily 2% testosterone solution (T-sol) is safe and effective for sex drive and energy in hypogonadal men.

Frozen vs Fresh Embryos for IVF in Polycystic Ovary Syndrome

Frozen vs Fresh Embryos for IVF in Polycystic Ovary Syndrome

For women with polycystic ovary syndrome (PCOS) seeking infertility treatment, the use of frozen embryos rather than fresh appears to improve the chances for a successful pregnancy.

Anxiety, Depression Symptoms Common With Fertility Treatment

Anxiety, Depression Symptoms Common With Fertility Treatment

Patients undergoing fertility treatment often suffer symptoms of depression or anxiety, but few get any formal help.

Study Suggests Soy Isoflavones May Have Metabolic Benefits in PCOS

Study Suggests Soy Isoflavones May Have Metabolic Benefits in PCOS

Soy isoflavones were associated with lower levels of circulating insulin and biological markers of insulin resistance in polycystic ovary syndrome.

Does Birth Control Boost Vitamin D Levels in Women?

Does Birth Control Boost Vitamin D Levels in Women?

Use of estrogen-containing contraceptives were linked to significantly higher vitamin D levels.

Metabolic Syndrome Severity May Change Throughout Menopausal Transition

Metabolic Syndrome Severity May Change Throughout Menopausal Transition

African-American women in particular experienced more rapid progression in metabolic syndrome severity during pre- and perimenopausal periods compared to post-menopausal period.

Is There an Association Between Sex Hormones, Sleep, and Lifestyle?

Is There an Association Between Sex Hormones, Sleep, and Lifestyle?

Researchers found sleep apnea and daytime sleepiness were related to sex hormones, but other factors may play a role.

Breast Cancer Risk No Higher With IVF Treatment

Breast Cancer Risk No Higher With IVF Treatment

Women who undergo in vitro fertilization (IVF) are not at increased risk of breast cancer, according to a study published in the Journal of the American Medical Association.

High Levels of Urinary Paracetamol May Affect Fertility in Men

High Levels of Urinary Paracetamol May Affect Fertility in Men

Time to pregnancy was longer for couples in which the male partner had higher urinary paracetamol concentrations.

PMS, PMDD Tied to Increased Odds for Bulimia

PMS, PMDD Tied to Increased Odds for Bulimia

Premenstrual syndrome and premenstrual dysphoric disorder are associated with increased odds of bulimia nervosa, but not with binge-eating disorder.

Factors Related to Temporal Patterns of Vasomotor Symptoms During Menopause Identified

Factors Related to Temporal Patterns of Vasomotor Symptoms During Menopause Identified

Researchers identified 4 distinct trajectories of vasomotor symptoms predicted by reproductive hormones, race and ethnicity, BMI, and psychosocial characteristics.

Ovarian Reserve Not Impacted by Opportunistic Salpingectomy

Ovarian Reserve Not Impacted by Opportunistic Salpingectomy

Opportunistic salpingectomy conducted at the time of laparoscopic hysterectomy does not appear to negatively affect ovarian reserve or increase surgical risk.

Diagnosis, Management of PCOS Discussed in Case Vignette

Diagnosis, Management of PCOS Discussed in Case Vignette

The diagnosis and management of polycystic ovary syndrome (PCOS) was discussed in a case vignette published in The New England Journal of Medicine.

Testosterone Gel Moderately Improved Sexual Function in Older Men

Testosterone Gel Moderately Improved Sexual Function in Older Men

Men using testosterone gel experienced improvements in sex drive, sexual activity, and erectile function.

Abnormal Adrenal Function May Affect Some Women With PCOS

Abnormal Adrenal Function May Affect Some Women With PCOS

A portion of women with polycystic ovary syndrome may experience excess adrenal hormone production.

Phytoestrogen Supplementation May Reduce Menopause Symptoms

Phytoestrogen Supplementation May Reduce Menopause Symptoms

The review shows modest reductions in frequency of hot flashes and vaginal dryness, but not in night sweats.

Depressive Symptoms Inversely Linked to Fecundability

Depressive Symptoms Inversely Linked to Fecundability

Depressive symptoms are associated with reduced fecundability, according to a study published in the American Journal of Obstetrics and Gynecology.

Late Luteal Phase Estrogen Levels Dropped More Rapidly in Women With Migraine

Late Luteal Phase Estrogen Levels Dropped More Rapidly in Women With Migraine

The findings suggest a neuroendocrine vulnerability in women with migraine.

Smoking Cessation May Be Easier During Certain Menstrual Cycle Phase

Smoking Cessation May Be Easier During Certain Menstrual Cycle Phase

Women may find it easier to resist the urge to smoke after ovulation.

In Obese Women, Lifestyle Intervention Before Infertility Treatment Not Beneficial

In Obese Women, Lifestyle Intervention Before Infertility Treatment Not Beneficial

Lifestyle intervention preceding infertility treatment does not increase vaginal birth rates in obese women.

Hormone Therapy May Increase Multiple Sclerosis Risk in Some Transgender Patients

Hormone Therapy May Increase Multiple Sclerosis Risk in Some Transgender Patients

Researchers hypothesized that an altered balance of sex hormones in men with gender identity disorder would increase the risk of MS.

Metformin, Oral Contraceptives May Benefit Adolescents With PCOS

Metformin, Oral Contraceptives May Benefit Adolescents With PCOS

Four randomized controlled trials show benefits for metformin and oral contraceptive pills.

BRCA1 Mutation May Affect Fertility in Women

BRCA1 Mutation May Affect Fertility in Women

The BRCA1 mutation may speed the aging of a woman's ovaries.

Paroxetine Reduced Vasomotor Symptoms During, After Menopause

Paroxetine Reduced Vasomotor Symptoms During, After Menopause

Moderate-quality evidence shows a reduction in the frequency of hot flashes with paroxetine.

Testosterone Undecanoate May Reduce Anemia in Men With Hypogonadism

Testosterone Undecanoate May Reduce Anemia in Men With Hypogonadism

Results showed a decreased prevalence of anemia and components of metabolic syndrome after 54 weeks of treatment.

Oral Progesterone May Attenuate Drug-Induced QT Interval Lengthening

Oral Progesterone May Attenuate Drug-Induced QT Interval Lengthening

Findings in healthy females who received progesterone or placebo for 7 days.

Breast Cancer Patients Could Manage Hot Flashes with Acupuncture

Breast Cancer Patients Could Manage Hot Flashes with Acupuncture

Researchers observed improvements in climacteric symptoms and quality of life measures.

What Is the Economic Impact of Endocrine-Disrupting Chemical Exposure?

What Is the Economic Impact of Endocrine-Disrupting Chemical Exposure?

Health care costs associated with endocrine-disrupting chemicals exceed €1 billion in the European Union.

Evaluating Hyperandrogenemia in Polycystic Ovary Syndrome

Evaluating Hyperandrogenemia in Polycystic Ovary Syndrome

Researchers concluded that including androstenedione in the diagnosis of biochemical hyperandrogenism led to a prevalence of hyperandrogenic PCOS of more than 80%.

Estrogen Deficiency in Women Linked to Nonalcoholic Fatty Liver Disease

Estrogen Deficiency in Women Linked to Nonalcoholic Fatty Liver Disease

Duration of estrogen deficiency in women with nonalcoholic fatty liver disease may be more likely to have severe fibrosis.

Some Women Experience Lack of Interest in Sex After Initiating New Contraceptive

Some Women Experience Lack of Interest in Sex After Initiating New Contraceptive

Almost one-quarter of women report lacking interest in sex at 6 months after initiating a new contraceptive method.

Stroke Risk Higher in Women on Hormone Therapy With Worsening Migraines

Stroke Risk Higher in Women on Hormone Therapy With Worsening Migraines

More than 20% of women currently using hormone replacement therapy experienced an increase in migraine severity.

Pregnancy at an Advanced Age May Up Stroke Risk After Menopause

Pregnancy at an Advanced Age May Up Stroke Risk After Menopause

Postmenopausal women whose last pregnancy occurred at 40 years of age or older may have a greater risk of hemorrhagic stroke.

Topical Testosterone Effectively Restores Normal Testosterone Levels in Men

Topical Testosterone Effectively Restores Normal Testosterone Levels in Men

Daily topical testosterone restored normal testosterone levels in hypogonadal men

Breast Cancer Patients May Regain Ovarian Function With Letrozole After Chemotherapy

Breast Cancer Patients May Regain Ovarian Function With Letrozole After Chemotherapy

Women 40 to 49 years of age with breast cancer regained ovarian function after chemotherapy with letrozole treatment.

Clinical Pregnancy Rates Lower for Some Ethnic Groups After In Vitro Fertilization

Clinical Pregnancy Rates Lower for Some Ethnic Groups After In Vitro Fertilization

Five US registry-based studies showed that black, Hispanic, and Asian women had lower clinical pregnancy rates after IVF compared with white women.

Continuous Oral Contraceptive More Effective After Endometriosis Surgery

Continuous Oral Contraceptive More Effective After Endometriosis Surgery

A continuous schedule was associated with lower recurrence rates for dysmenorrhea.

Certain Antidepressants Associated With Increased Risk for Postpartum Hemorrhage

Certain Antidepressants Associated With Increased Risk for Postpartum Hemorrhage

Exposure to serotonin-norepinephrine reuptake inhibitors in late pregnancy is associated with increased risk for postpartum hemorrhage.

Sedentary Women Experienced Worse Menopause Symptoms

Sedentary Women Experienced Worse Menopause Symptoms

Sedentary lifestyles were common among middle-aged Hispanic women and were also associated with worse menopausal symptoms.

Soy May Protect Against Harmful Reproductive Effects of BPA

Soy May Protect Against Harmful Reproductive Effects of BPA

Eating soy regularly may protect women who are undergoing infertility treatment from poor success due to BPA exposure.

Estrogen Compounds Reduced Flu in Cells From Women

Estrogen Compounds Reduced Flu in Cells From Women

Other studies have shown that estrogens have antiviral properties against HIV, Ebola, and hepatitis viruses.

Gene Mutations Linked to Form of Infertility in Women

Gene Mutations Linked to Form of Infertility in Women

For a small number of women with a rare form of infertility, mutations in a the TUBB8 gene may be the cause

Chinese Medicine Acupuncture Not Superior for Treatment of Menopausal Hot Flashes

Chinese Medicine Acupuncture Not Superior for Treatment of Menopausal Hot Flashes

Noninsertive sham acupuncture is a superior treatment option for menopausal women with hot flashes compared to Chinese medicine acupuncture.

Average Age of First-Time Mothers on the Rise

Average Age of First-Time Mothers on the Rise

From 2000 to 2014, the age of first-time mothers increased 1.4 years — from 24.9 years old on average to 26.3 years

Minimal Stimulation IVF Associated With Lower Live Birth Rates

Minimal Stimulation IVF Associated With Lower Live Birth Rates

Minimal stimulation in vitro fertilization (mini-IVF) is associated with reduced live birth rates compared with conventional IVF.

Delaying Pregnancy After Early Loss Not Beneficial

Delaying Pregnancy After Early Loss Not Beneficial

For couples with early pregnancy loss, there is no indication of improved live birth rates with delayed next attempt at pregnancy.

Oral Fluconazole Exposure Tied to Spontaneous Abortion Risk

Oral Fluconazole Exposure Tied to Spontaneous Abortion Risk

Use of oral fluconazole in pregnancy is associated with increased risk for spontaneous abortion, according to a study published in JAMA.

DHEA Suppository May Improve Vaginal Symptoms of Menopause

DHEA Suppository May Improve Vaginal Symptoms of Menopause

For postmenopausal women, suppositories containing the hormone dehydroepiandrosterone (DHEA) may reduce vaginal dryness, discomfort, and pain during sex without raising overall estrogen levels.

Infertility Treatment Not Linked to Developmental Delays in Children

Infertility Treatment Not Linked to Developmental Delays in Children

Children conceived through infertility treatment are no more likely to experience developmental delays than those conceived without the treatment.

Opioid Exposure May Increase Odds for Low Testosterone

Opioid Exposure May Increase Odds for Low Testosterone

Researchers found an increased odds of low testosterone with exposure as well as an increased odds with increasing age and comorbidities.

Potential Discontinuation of Testosterone Nasal Gel Supply in 2016

Potential Discontinuation of Testosterone Nasal Gel Supply in 2016

Acerus announced that its agreement with an affiliate of Endo International plc regarding the commercialization of Natesto (testosterone) nasal gel in the U.S. and Mexico will be terminated as of June 30, 2016.

Triptorelin With Breast Cancer Chemotherapy May Increase Ovarian Recovery

Triptorelin With Breast Cancer Chemotherapy May Increase Ovarian Recovery

Adding triptorelin to breast cancer chemotherapy may increase ovarian recovery.

Risk for Infertility, Early Menopause Up With Active Tobacco Exposure

Risk for Infertility, Early Menopause Up With Active Tobacco Exposure

Active smoking and secondhand smoke exposure increases the risk for infertility and natural menopause before age 50.

Vulvovaginal Symptoms Impact Lives of Many Postmenopausal Women

Vulvovaginal Symptoms Impact Lives of Many Postmenopausal Women

Common vulvovaginal symptoms can have emotional, lifestyle, and sexual effects in postmenopausal women.

Men With Infertility At Increased Risk for Health Problems

Men With Infertility At Increased Risk for Health Problems

Men with infertility had significantly increased risks for diabetes, ischemic heart disease, alcohol abuse, and drug abuse.

High Testosterone Levels May Increase Risk for Uterine Fibroids

High Testosterone Levels May Increase Risk for Uterine Fibroids

High levels of testosterone and estrogen may raise a woman's risk for uterine fibroids.

Fracking Chemicals Linked to Reduced Sperm Count in Mice

Fracking Chemicals Linked to Reduced Sperm Count in Mice

Prenatal exposure to oil and gas chemicals used in hydraulic fracturing could cause reproductive health problems.

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