ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

ALDACTONE
CHF and arrhythmias
Edema
Hypertension
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

ALDACTONE Rx

Generic Name and Formulations:
Spironolactone 25mg, 50mg+, 100mg+; tabs; +scored.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for ALDACTONE:

Treatment of NYHA class III–IV heart failure and reduced ejection fraction to increase survival, manage edema, and reduce the need for hospitalization for heart failure, when used in addition to standard therapy.

Adult:

Serum potassium ≤5.0mEq/L and eGFR >50mL/min: initially 25mg daily; may increase to 50mg daily if tolerant, or decrease to 25mg every other day if hyperkalemia develops. eGFR 30–50mL/min: consider initiating at 25mg every other day.

Children:

Not established.

Contraindications:

Hyperkalemia. Addison's disease. Concomitant eplerenone.

Warnings/Precautions:

Increased risk of hyperkalemia in renal impairment; reduce dose or discontinue if occurs. Monitor serum potassium within 1 week of initiation or titration and periodically thereafter (more frequently if clinically indicated). Monitor volume status, renal function (esp. elderly), electrolytes, uric acid, blood glucose periodically. Salt-depleted. Hepatic impairment. Pregnancy (avoid). Nursing mothers.

Interactions:

Increased risk of severe hyperkalemia with concomitant K+ supplements, K+ containing salt substitutes, or drugs that increase potassium (eg, ACEIs, ARBs, NSAIDs, heparin, LMWH, trimethoprim); discontinue K+ supplements in heart failure patients. Hyperkalemic metabolic acidosis with cholestyramine. May be antagonized by NSAIDs, acetylsalicylic acid (may need to increase spironolactone dose); monitor. Monitor lithium. May interfere with digoxin assays.

Pharmacological Class:

Diuretic (K+ sparing).

Adverse Reactions:

Gynecomastia, GI upset, dizziness, drowsiness, headache, leg cramps, renal dysfunction; hypotension, hyperglycemia, hyperuricemia, hyperkalemia, and other electrolyte disturbances.

Generic Availability:

YES

How Supplied:

Tabs—100

Indications for ALDACTONE:

Edema due to liver cirrhosis or nephrotic syndrome. Edema in patients with hypokalemia due to other diuretics.

Adult:

Initially 100mg/day in single or divided doses; usual range 25–200mg daily. Maintain for at least 5 days, then retitrate. Cirrhosis: initiate in hospital setting; titrate slowly.

Children:

Not established.

Contraindications:

Hyperkalemia. Addison's disease. Concomitant eplerenone.

Warnings/Precautions:

Increased risk of hyperkalemia in renal impairment; reduce dose or discontinue if occurs. Monitor serum potassium within 1 week of initiation or titration and periodically thereafter (more frequently if clinically indicated). Monitor volume status, renal function (esp. elderly), electrolytes, uric acid, blood glucose periodically. Salt-depleted. Hepatic impairment. Pregnancy (avoid). Nursing mothers.

Interactions:

Increased risk of severe hyperkalemia with concomitant K+ supplements, K+ containing salt substitutes, or drugs that increase potassium (eg, ACEIs, ARBs, NSAIDs, heparin, LMWH, trimethoprim); discontinue K+ supplements in heart failure patients. Hyperkalemic metabolic acidosis with cholestyramine. May be antagonized by NSAIDs, acetylsalicylic acid (may need to increase spironolactone dose); monitor. Monitor lithium. May interfere with digoxin assays.

Pharmacological Class:

Diuretic (K+ sparing).

Adverse Reactions:

Gynecomastia, GI upset, dizziness, drowsiness, headache, leg cramps, renal dysfunction; hypotension, hyperglycemia, hyperuricemia, hyperkalemia, and other electrolyte disturbances.

Generic Availability:

YES

How Supplied:

Tabs—100

Indications for ALDACTONE:

Adjunct in hypertension.

Adult:

Initially 25–100mg/day in single or divided doses. Titrate at 2 week intervals.

Children:

Not established.

Contraindications:

Hyperkalemia. Addison's disease. Concomitant eplerenone.

Warnings/Precautions:

Increased risk of hyperkalemia in renal impairment; reduce dose or discontinue if occurs. Monitor serum potassium within 1 week of initiation or titration and periodically thereafter (more frequently if clinically indicated). Monitor volume status, renal function (esp. elderly), electrolytes, uric acid, blood glucose periodically. Salt-depleted. Hepatic impairment. Pregnancy (avoid). Nursing mothers.

Interactions:

Increased risk of severe hyperkalemia with concomitant K+ supplements, K+ containing salt substitutes, or drugs that increase potassium (eg, ACEIs, ARBs, NSAIDs, heparin, LMWH, trimethoprim); discontinue K+ supplements in heart failure patients. Hyperkalemic metabolic acidosis with cholestyramine. May be antagonized by NSAIDs, acetylsalicylic acid (may need to increase spironolactone dose); monitor. Monitor lithium. May interfere with digoxin assays.

Pharmacological Class:

Diuretic (K+ sparing).

Adverse Reactions:

Gynecomastia, GI upset, dizziness, drowsiness, headache, leg cramps, renal dysfunction; hypotension, hyperglycemia, hyperuricemia, hyperkalemia, and other electrolyte disturbances.

Generic Availability:

YES

How Supplied:

Tabs—100

Sign Up for Free e-Newsletters



CME Focus