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ACTICLATE
Acne
Bacterial infections
Malaria
Protozoal infections
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Drug Name:

ACTICLATE Rx

Generic Name and Formulations:
Doxycycline (as hyclate) 75mg, 150mg+; tabs; +scored; contains sodium.

Company:
Aqua Pharmaceuticals

Therapeutic Use:

Indications for ACTICLATE:

Adjunct in severe acne.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12 hours), then 100mg daily (as a single dose or 50mg every 12 hours).

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); (≥45kg): use Adults dose.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or other severe skin reaction, superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy (Cat.D), nursing mothers: not recommended.

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea.

How Supplied:

Tabs—60

Indications for ACTICLATE:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Anthrax, including inhalational anthrax (postexposure). Alternative for selected infections when penicillin is contraindicated.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12 hours), then 100mg daily (as a single dose or 50mg every 12 hours); if severe infections (eg, chronic UTI): 100mg every 12 hours. Streptococcal infections: treat for 10 days. Uncomplicated urethral, endocervical, rectal infection, or nongonococcal urethritis (NGU): 100mg twice daily for 7 days. Uncomplicated gonococcal infections (except anorectal infections in men): 100mg twice daily for 7 days or 300mg single dose followed by a second 300mg dose 1 hr later. Syphilis (early): 100mg twice daily for 2 weeks; if >1yr duration: treat for 4 weeks. Acute epididymo-orchitis: 100mg twice daily for at least 10 days. Anthrax: 100mg twice daily for 60 days.

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); if severe infections: 2.2mg/kg every 12hrs; (≥45kg): use Adults dose. Anthrax (<45kg): 2.2mg/kg twice daily for 60 days; (≥45kg): use Adults dose.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or other severe skin reaction, superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy (Cat.D), nursing mothers: not recommended.

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea.

How Supplied:

Tabs—60

Indications for ACTICLATE:

Short term prophylaxis of malaria due to P. falciparum in areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strains.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. 100mg daily; begin 1–2 days before, continue during and 4 weeks after travel to malarious area.

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. ≥8yrs (<45kg): 2mg/kg once daily; (≥45kg): use Adults dose; begin 1–2 days before, continue during and 4 weeks after travel to malarious area.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or other severe skin reaction, superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy (Cat.D), nursing mothers: not recommended.

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea.

How Supplied:

Tabs—60

Indications for ACTICLATE:

Adjunct in acute intestinal amebiasis.

Adult:

Take with fluids; may give with food or milk if gastric irritation occurs. 200mg for 1 day (100mg every 12 hours), then 100mg daily (as a single dose or 50mg every 12 hours); if severe infections: 100mg every 12 hours.

Children:

≤8yrs: not usually recommended. Take with fluids; may give with food or milk if gastric irritation occurs. >8yrs (<45kg): 4.4mg/kg in 2 divided doses for 1 day, then 2.2mg/kg daily (as a single dose or divided as 2 doses); if severe infections: 2.2mg/kg every 12hrs; (≥45kg): use Adults dose.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Discontinue if skin erythema or other severe skin reaction, superinfection develops. Avoid sun or UV light. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Pregnancy (Cat.D), nursing mothers: not recommended.

Pharmacological Class:

Tetracycline antibiotic.

Interactions:

Avoid concomitant penicillins, isotretinoin. Fatal renal toxicity with concomitant methoxyflurane. May need to reduce concomitant anticoagulant dose. Absorption reduced by antacids containing aluminum, calcium, magnesium, bismuth subsalicylate and iron. May be antagonized by barbiturates, carbamazepine, phenytoin. May antagonize oral contraceptives. May interfere with fluorescence test.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, delayed skeletal development, intracranial hypertension, C.difficile-associated diarrhea.

How Supplied:

Tabs—60

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