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ABLAVAR
Imaging agents
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Drug Name:

ABLAVAR Rx

Generic Name and Formulations:
Gadofosveset trisodium 244mg/mL (0.25mmol/mL); soln for IV inj.

Company:
Lantheus Medical Imaging

Therapeutic Use:

Indications for ABLAVAR:

For use as a contrast agent in magnetic resonance angiography (MRA) to evaluate aortoiliac occlusive disease (AIOD) in adults with known or suspected peripheral vascular disease.

Adult:

Give as IV bolus inj over 30 seconds followed by 25–30mL normal saline flush. 0.12mL/kg (0.03mmol/kg). See full labeling for imaging guidelines.

Children:

<18yrs: not established.

Warnings/Precautions:

Chronic, severe kidney disease (GFR<30mL/min/1.73m2), acute kidney injury: increased risk of nephrogenic systemic fibrosis; avoid unless necessary, allow sufficient period of time for elimination prior to re-administration. Screen for acute kidney injury and other conditions that reduce renal function (eg, >60yrs, hypertension, diabetes). Anaphylactoid reaction possible (may be fatal); discontinue immediately if occurs; have emergency resuscitative equipment available. History of drug reactions, asthma, allergy or other hypersensitivity disorders. Risk of QTc prolongation; consider obtaining baseline ECG to assess risk, consider follow up ECG and risk reduction measures until contrast agent eliminated. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Caution with concomitant drugs that bind to albumin.

Pharmacological Class:

Gadolinium-based contrast agent.

Adverse Reactions:

Pruritus, headache, nausea, vasodilation, paresthesia, inj site bruising, dysgeusia, burning sensation, venipuncture site bruise, hypertension, dizziness, feeling cold; hypersensitivity reactions.

How Supplied:

Single-use vials (10mL, 15mL)—10

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