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ABELCET
Fungal infections
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Drug Name:

ABELCET Rx

Generic Name and Formulations:
Amphotericin B lipid complex 5mg/mL; susp for IV infusion after dilution; preservative-free.

Company:
Sigma-Tau Pharmaceuticals, Inc.

Therapeutic Use:

Indications for ABELCET:

Invasive fungal infections in patients who are refractory to, or intolerant of, conventional amphotericin B therapy.

Adults and Children:

5mg/kg daily as a single IV infusion, at a rate of 2.5mg/kg per hour. Renal impairment: reduce dose.

Warnings/Precautions:

Be fully familiar with the use of this product. Administer under close supervision; cardiopulmonary resuscitation facilities should be available. Monitor CBC, serum creatinine, liver function, serum electrolytes (esp. magnesium and potassium). Pregnancy (Cat.B). Nursing mothers: not recommended.

Interactions:

Monitor other drugs; see literature. Caution with antineoplastics, corticosteroids, ACTH, cyclosporine, digitalis glycosides, flucytosine, imidazoles, nephrotoxic drugs, skeletal muscle relaxants, zidovudine. Concurrent leukocyte transfusion: not recommended.

Pharmacological Class:

Polyene antifungal.

Adverse Reactions:

Infusion reactions (1–2 hrs post-infusion, e.g., transient chills/fever, rarely: bronchospasm, hypotension, arrhythmias, shock), nephrotoxicity, hepatotoxicity, anaphylaxis, respiratory/cardiac/neurological disorders, malaise, tinnitus, visual impairment, hearing loss, diarrhea; others: see literature.

How Supplied:

Single-use vials (50mg, 100mg)—1 (w. filter needle)

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