Does Vitamin D Supplementation Affect Subclinical Hypothyroidism

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Researchers noted a significant increase in serum vitamin D and significant reductions in TSH following 3 months of vitamin D supplementation.
Researchers noted a significant increase in serum vitamin D and significant reductions in TSH following 3 months of vitamin D supplementation.

A significant decrease in thyroid stimulating hormone (TSH) level and anti TPO titre was seen when patients with autoimmune subclinical hypothyroidism (SCH) and vitamin D deficiency received vitamin D replacement, according to a study presented at the the 26th American Association of Clinical Endocrinologists Annual Scientific Sessions & Clinical Congress. 

To date, there have been no studies assessing the outcome of vitamin D replacement on SCH. Study authors from King Fahad Medical City and King Abdualziz Medical City, led by Naji Aljohani, MD, SBIM, FACE, FACP, hypothesized that replacing vitamin D in deficient patients with SCH would result in reduced TSH levels and anti TPO titres. To test this, they performed an observational, prospective study in Saudi patients with SCH and vitamin D deficiency. 

At baseline, the mean TSH was 6.0 mIU/L, mean Free T4 was 14.4 pmol/L, mean anti TPO antibody titre was 343.4 IU/mL, and mean vitamin D level was 25.2 nmol/L. 

After 3 months of treatment with vitamin D, the researchers found a significant increase in serum vitamin D to 59.6 nmol/L (=.0001) as well as significant reductions in TSH to 4.9 mIU/L (=.001) and anti TPO titre to 125.1 IU/mL (=.057). 

"We showed that replacing vitamin D has a significant impact on improving SCH, measured by a significant reduction in both TSH and anti TPO antibody titre after 3 months of treatment," said Dr Aljohani. A subgroup stratified by vitamin D status, however, indicated that the reduction was only significant for those with vitamin D deficiency. 

Due to the small sample size, the authors acknowledge that bigger randomized controlled trials are needed to validate these findings.


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Reference

Aljohani N, Brema I, Ansari M, Khan S, Almousawi F, AlSharani A. The effect of vitamin D replacement on subclinical hypothyroidism. Abstract 1073. Presented at: 26th American Association of Clinical Endocrinologists Annual Scientific Sessions & Clinical Congress; May 3-7, 2017; Austin, TX.


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