Higher In-Hospital Mortality Rates in Type 1 vs Type 2 Diabetes With Acute MI
Hospital costs were not statistically significant between type 1 and type 2 diabetes.
This article is part of Endocrinology Advisor's coverage of the 26th American Association of Clinical Endocrinologists (AACE) Annual Scientific Sessions & Clinical Congress, taking place in Austin, Texas. Our staff will report on medical research and technological advances in diabetes, obesity, and thyroid conditions, conducted by experts in the field. Check back regularly for more news from AACE 2017.
In-hospital mortality in patients with type 1 diabetes admitted for acute myocardial infarction (AMI) was significantly higher compared with patients with type 2 diabetes, according to a retrospective cohort study presented at the 26th Annual Scientific & Clinical Congress of the American Association of Clinical Endocrinologists (AACE), May 3-7, in Austin, Texas.
Researchers from Mount Sinai West and Mount Sinai St. Luke's in New York City included 226,956 patients from the 2013 National Inpatient Sample. Almost 98% of these patients (n=221,310) had type 2 diabetes and 2.5% had type 1 diabetes (n=5,655).The mean age of the total population was 67.38, but by group the mean age was lower in patients with type 1 diabetes (57.8).
When compared with patients with type 2 diabetes, patients with type 1 diabetes had an increased adjusted inpatient mortality rate (odds ratio 1.49; 95% CI, 1.12-1.99; P <.01). Patients with type 1 diabetes also had a longer length of hospital stay by 0.5 days (P =.02). Hospital costs, however, were not statistically significant between groups.
“There has been conflicting evidence when comparing cardiovascular mortality in patients with [type 1 diabetes] and [type 2 diabetes],” the researchers wrote. “Despite this, [type 1 diabetes] has been shown to cause earlier endothelial damage and autonomic dysinnervation causing impaired vasodilator response of coronary vessels when compared [with] patients with [type 2 diabetes].”
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Vallejo F, Hurtado C, Lopez K, Garcia R, Albu J. In-hospital mortality in patients admitted for acute myocardial infarction: type 1 diabetes mellitus compared to type 2 diabetes mellitus. Abstract 289. Presented at: the 26th Annual Scientific & Clinical Congress of the American Association of Clinical Endocrinologists. May 3-7, 2017; Austin, TX.